Accelerated atherosclerosis in rheumatoid arthritis

Daniel Shepshelovich, Yaniv Sherer, Yehuda Shoenfeld

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Cardiovascular manifestations are frequent in rheumatoid arthritis (RA) and significantly contribute to morbidity and mortality in this disorder. Premature atherosclerosis is responsible for these complications, as supported by autopsy studies. Moreover, a high prevalence of sub-clinical atherosclerosis - evaluated by imaging and instrumental parameters - has been reported. Traditional risk factors cannot completely account for accelerated atherosclerosis in RA. The presence of RA by itself and the immunosuppressive therapy (especially corticosteroids) represent non-traditional risk factors for premature atherosclerosis. Additional factors playing a synergistic role in the atherosclerotic process are systemic chronic inflammation frequently associated with RA and both humoral and cellular specific autoimmune responses. Herein we review and discuss atherosclerosis in rheumatoid arthritis, with special emphasis on clinical presentations, pathogenesis and therapy.

Original languageEnglish
Pages (from-to)561-563
Number of pages3
JournalHarefuah
Volume144
Issue number8
StatePublished - 9 Dec 2005

Keywords

  • Atherosclerosis
  • Rheumatoid arthritis

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