TY - GEN
T1 - Accurate determination of radionuclide purity and half-life of reactor produced LU-177G for metabolic radioimmunotherapy
AU - Groppi, F.
AU - Canella, L.
AU - Bonardi, M. L.
AU - Zona, C.
AU - Morzenti, S.
AU - Menapace, E.
AU - Alfassi, Z. B.
AU - Chinol, M.
AU - Papi, S.
AU - Tosi, G.
PY - 2006/1/1
Y1 - 2006/1/1
N2 - The accurate determination of radionuclidic purity and half-life of the beta emitter 177gLu used for metabolic radioimmunotherapy is presented. High-resolution gamma spectrometry, as well as deconvolution of beta decay curve measured by spectrometry with liquid scintillation counting, have been adopted for quality control of different samples available on the market. A simple method was developed to distinguish between the different methods available for production of 177gLu: i.e. either direct (n,y) reactions of enriched 176Lu or indirect (n,y) activation of enriched 176Yb followed by P" decay. In the first case, the long-lived metastable level 177mLu is present in the radioactive preparation and a low specific activity radionuclide is obtained, in the latter a very high purity and high specific activity 177gLu is produced.
AB - The accurate determination of radionuclidic purity and half-life of the beta emitter 177gLu used for metabolic radioimmunotherapy is presented. High-resolution gamma spectrometry, as well as deconvolution of beta decay curve measured by spectrometry with liquid scintillation counting, have been adopted for quality control of different samples available on the market. A simple method was developed to distinguish between the different methods available for production of 177gLu: i.e. either direct (n,y) reactions of enriched 176Lu or indirect (n,y) activation of enriched 176Yb followed by P" decay. In the first case, the long-lived metastable level 177mLu is present in the radioactive preparation and a low specific activity radionuclide is obtained, in the latter a very high purity and high specific activity 177gLu is produced.
UR - http://www.scopus.com/inward/record.url?scp=84885722985&partnerID=8YFLogxK
U2 - 10.1142/9789812773678_0112
DO - 10.1142/9789812773678_0112
M3 - Conference contribution
AN - SCOPUS:84885722985
SN - 9812567984
SN - 9789812567987
T3 - Astroparticle, Particle and Space Physics, Detectors and Medical Physics Applications - Proceedings of the 9th Conference
SP - 710
EP - 714
BT - Astroparticle, Particle and Space Physics, Detectors and Medical Physics Applications - Proceedings of the 9th Conference
PB - World Scientific Publishing Co. Pte Ltd
T2 - International Conference on Advanced Technology and Particle Physics, ICATPP 2005
Y2 - 17 October 2005 through 21 October 2005
ER -