Acemetacin polymorphs: A rare case of carboxylic acid catemer and dimer synthons

Palash Sanphui; Geetha Bolla; Uday Das; Alok K. Mukherjee; Ashwini Nangia

doi:10.1039/c2ce26534f

Acemetacin polymorphs: A rare case of carboxylic acid catemer and dimer synthons

Palash Sanphui, Geetha Bolla, Uday Das, Alok K. Mukherjee, Ashwini Nangia

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70 Scopus citations

Abstract

Acemetacin is the first example of an API polymorph with a carboxylic acid catemer and dimer O-H⋯O synthons. The auxiliary stabilization to the catemer motif from stronger C-H⋯O and C-Cl⋯O interactions compared to those in the dimer structure is discussed for a polymorph pair. The crystal structure of the stable dimer polymorph was solved by structure determination from powder X-ray diffraction data (SDPD).

Original language	English
Pages (from-to)	34-38
Number of pages	5
Journal	CrystEngComm
Volume	15
Issue number	1
DOIs	https://doi.org/10.1039/c2ce26534f
State	Published - 7 Jan 2013
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
General Materials Science
Condensed Matter Physics

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abstract = "Acemetacin is the first example of an API polymorph with a carboxylic acid catemer and dimer O-H⋯O synthons. The auxiliary stabilization to the catemer motif from stronger C-H⋯O and C-Cl⋯O interactions compared to those in the dimer structure is discussed for a polymorph pair. The crystal structure of the stable dimer polymorph was solved by structure determination from powder X-ray diffraction data (SDPD).",

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AU - Mukherjee, Alok K.

AU - Nangia, Ashwini

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AB - Acemetacin is the first example of an API polymorph with a carboxylic acid catemer and dimer O-H⋯O synthons. The auxiliary stabilization to the catemer motif from stronger C-H⋯O and C-Cl⋯O interactions compared to those in the dimer structure is discussed for a polymorph pair. The crystal structure of the stable dimer polymorph was solved by structure determination from powder X-ray diffraction data (SDPD).

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Acemetacin polymorphs: A rare case of carboxylic acid catemer and dimer synthons

Abstract

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