Acemetacin polymorphs: A rare case of carboxylic acid catemer and dimer synthons

Palash Sanphui, Geetha Bolla, Uday Das, Alok K. Mukherjee, Ashwini Nangia

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

Acemetacin is the first example of an API polymorph with a carboxylic acid catemer and dimer O-H⋯O synthons. The auxiliary stabilization to the catemer motif from stronger C-H⋯O and C-Cl⋯O interactions compared to those in the dimer structure is discussed for a polymorph pair. The crystal structure of the stable dimer polymorph was solved by structure determination from powder X-ray diffraction data (SDPD).

Original languageEnglish
Pages (from-to)34-38
Number of pages5
JournalCrystEngComm
Volume15
Issue number1
DOIs
StatePublished - 7 Jan 2013
Externally publishedYes

ASJC Scopus subject areas

  • General Chemistry
  • General Materials Science
  • Condensed Matter Physics

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