Acemetacin polymorphs: A rare case of carboxylic acid catemer and dimer synthons

Palash Sanphui; Geetha Bolla; Uday Das; Alok K. Mukherjee; Ashwini Nangia

doi:10.1039/c2ce26534f

Acemetacin polymorphs: A rare case of carboxylic acid catemer and dimer synthons

Palash Sanphui
, Geetha Bolla
, Uday Das
, Alok K. Mukherjee
, Ashwini Nangia

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

Acemetacin is the first example of an API polymorph with a carboxylic acid catemer and dimer O-H⋯O synthons. The auxiliary stabilization to the catemer motif from stronger C-H⋯O and C-Cl⋯O interactions compared to those in the dimer structure is discussed for a polymorph pair. The crystal structure of the stable dimer polymorph was solved by structure determination from powder X-ray diffraction data (SDPD).

Original language	English
Pages (from-to)	34-38
Number of pages	5
Journal	CrystEngComm
Volume	15
Issue number	1
DOIs	https://doi.org/10.1039/c2ce26534f
State	Published - 7 Jan 2013
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
General Materials Science
Condensed Matter Physics

Access to Document

10.1039/c2ce26534f

Cite this

@article{99d354b87a6d425d81f7e8c9ce41953d,

title = "Acemetacin polymorphs: A rare case of carboxylic acid catemer and dimer synthons",

abstract = "Acemetacin is the first example of an API polymorph with a carboxylic acid catemer and dimer O-H⋯O synthons. The auxiliary stabilization to the catemer motif from stronger C-H⋯O and C-Cl⋯O interactions compared to those in the dimer structure is discussed for a polymorph pair. The crystal structure of the stable dimer polymorph was solved by structure determination from powder X-ray diffraction data (SDPD).",

author = "Palash Sanphui and Geetha Bolla and Uday Das and Mukherjee, \{Alok K.\} and Ashwini Nangia",

year = "2013",

month = jan,

day = "7",

doi = "10.1039/c2ce26534f",

language = "English",

volume = "15",

pages = "34--38",

journal = "CrystEngComm",

issn = "1466-8033",

publisher = "Royal Society of Chemistry",

number = "1",

}

TY - JOUR

T1 - Acemetacin polymorphs

T2 - A rare case of carboxylic acid catemer and dimer synthons

AU - Sanphui, Palash

AU - Bolla, Geetha

AU - Das, Uday

AU - Mukherjee, Alok K.

AU - Nangia, Ashwini

PY - 2013/1/7

Y1 - 2013/1/7

N2 - Acemetacin is the first example of an API polymorph with a carboxylic acid catemer and dimer O-H⋯O synthons. The auxiliary stabilization to the catemer motif from stronger C-H⋯O and C-Cl⋯O interactions compared to those in the dimer structure is discussed for a polymorph pair. The crystal structure of the stable dimer polymorph was solved by structure determination from powder X-ray diffraction data (SDPD).

AB - Acemetacin is the first example of an API polymorph with a carboxylic acid catemer and dimer O-H⋯O synthons. The auxiliary stabilization to the catemer motif from stronger C-H⋯O and C-Cl⋯O interactions compared to those in the dimer structure is discussed for a polymorph pair. The crystal structure of the stable dimer polymorph was solved by structure determination from powder X-ray diffraction data (SDPD).

UR - https://www.scopus.com/pages/publications/84870165284

U2 - 10.1039/c2ce26534f

DO - 10.1039/c2ce26534f

M3 - Article

AN - SCOPUS:84870165284

SN - 1466-8033

VL - 15

SP - 34

EP - 38

JO - CrystEngComm

JF - CrystEngComm

IS - 1

ER -

Acemetacin polymorphs: A rare case of carboxylic acid catemer and dimer synthons

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this