Acromegaly due to ectopic growth hormone-releasing hormone secretion by a bronchial carcinoid tumour. Dynamic hormonal responses to various stimuli

M. Glikson, I. Gil-Ad, E. Galun, R. Dresner, S. Zilberman, Y. Halperin, E. Z. Okon Laron, A. Rubinow

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Ectopic GHRH is a relatively uncommon cause of acromegaly, which should be differentiated from pituitary adenoma, in order to avoid damage to the pituitary gland from unnecessary interventions. We report here on a 66-year-old man with acromegaly due to a GHRH-secreting bronchial carcinoid tumour, who recovered completely following removal of the tumour. His hormonal status was studied before and after the operation. Basal GH, GHRH, IGF-I and PRL levels, as well as plasma GH response to glucose load and TRH administration were abnormal before the operation, and became normal thereafter. The somatostatin analogue SMS 201995 was found to be a potent inhibitor of the ectopic GHRH and the GH secretion (>500 to 42 ng/l and 15.4 μg/l to 0.8 μg/l, respectively). The effect on GHRH proved to be due to direct effect of somatostatin on the tumour cells, as demonstrated in tissue culture studies. A mixed meal was found immediately to suppress GHRH levels without such an effect on GH secretion. We conclude that the neuroendocrine tests usually practised in acromegaly cannot differentiatc between ectopic GHRH secretion and pituitary adenoma. High plasma GHRH levels may serve as a diagnostic test for excessive GHRH production, which is almost always ectopic. These hign levels are suppressible by somatostatin and a mixed meal.

Original languageEnglish
Pages (from-to)366-371
Number of pages6
JournalActa Endocrinologica
Volume125
Issue number4
DOIs
StatePublished - 1 Jan 1991
Externally publishedYes

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