Activation of intestinal epithelial cells in Atlantic cod, Gadus morhua, induced by algal derivatives

Carlo C. Lazado, Christopher Marlowe A. Caipang

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


This study investigated the influences of two algal derivatives, alginic acid and fucoidan (FUC) on the activities of the intestinal epithelial cells (IEC) of Atlantic cod. The cells were isolated from three regions of the intestines, and primary cultures were incubated with the derivatives followed by temporal analysis of cellular activities. Epithelial cell survival in the fore and hind intestine was not significantly affected by the algal derivatives at both time points (3 and 24 h postincubation, hpi). Cellular survival in the mid-intestine decreased significantly at 3 hpi. Stimulation of myeloperoxidase (MPO) activity of IEC induced by the algal derivatives was observed to be region dependent. Myeloperoxidase activity in the cells from fore- and mid-intestines was not significantly affected by the two algal derivatives. Both algal derivatives significantly stimulated the activity at 3 hpi in the hind intestinal cells, and FUC-exposed cells remained significantly elevated until 24 hpi. The results showed that algal derivatives could be applied as potential immunostimulants in cod with stimulatory action of MPO activity in the mucosal immune cells of the hind intestine.

Original languageEnglish
Pages (from-to)1194-1199
Number of pages6
JournalAquaculture Research
Issue number8
StatePublished - 1 Jul 2012
Externally publishedYes


  • Alginic acid
  • Atlantic cod
  • Cellular response
  • Fucoidan
  • Gut

ASJC Scopus subject areas

  • Aquatic Science


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