Activity of PRC1 and Histone H2AK119 Monoubiquitination: Revising Popular Misconceptions

Idan Cohen, Carmit Bar, Elena Ezhkova

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

Polycomb group proteins are evolutionary conserved chromatin-modifying complexes, essential for the regulation of developmental and cell-identity genes. Polycomb-mediated transcriptional regulation is provided by two multi-protein complexes known as Polycomb repressive complex 1 (PRC1) and 2 (PRC2). Recent studies positioned PRC1 as a foremost executer of Polycomb-mediated transcriptional control. Mammalian PRC1 complexes can form multiple sub-complexes that vary in their core and accessory subunit composition, leading to fascinating and diverse transcriptional regulatory mechanisms employed by PRC1 complexes. These mechanisms include PRC1-catalytic activity toward monoubiquitination of histone H2AK119, a well-established hallmark of PRC1 complexes, whose importance has been long debated. In this review, the central roles that PRC1-catalytic activity plays in transcriptional repression are emphasized and the recent evidence supporting a role for PRC1 complexes in gene activation is discussed.

Original languageEnglish
Article number1900192
JournalBioEssays
Volume42
Issue number5
DOIs
StatePublished - 1 May 2020

Keywords

  • H2AK119ub
  • Polycomb
  • catalytic activity
  • histone modification
  • polycomb repressive complex 1
  • polycomb repressive complex 2
  • transcriptional activation

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