Acute and subchronic toxicity study of Tamra Bhasma (incinerated copper) prepared with and without Amritikarana

Swapnil Y. Chaudhari, Mukesh B. Nariya, R. Galib, Pradeep K. Prajapati

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Background Tamra Bhasma (TB) is one among herbo-metallic preparations extensively used in routine ayurvedic practice. In the present era, Bhasma preparations used in ayurvedic system of medicines are always under stern observations for containing heavy metals which may raise the question of safety aspect. Objective In the present study, TB prepared with and without Amritikarana was subjected to toxicity study to ascertain the role of Amritikarana on safety profile of TB in rats. Materials and methods Both the samples of TB were administered to rats for 28 consecutive days at the doses of 5.5, 27.5, and 55 mg/kg. The effects of both drugs were assessed on ponderal changes, hematological, serum biochemical, and histopathology of various organs. Results Results showed that both the samples of TB did not produce any sign and symptoms of toxicity at therapeutic dose level (5.5 mg/kg) and therapeutic equivalent dose (TED) × 5 (27.5 mg/kg) while at higher dose of TED × 10 (55 mg/kg) TB has mild toxicity in liver, kidney, heart, and thymus on repeated administration for 28 days in rats. The sample without Amritikarana has more magnitude of toxicity than the sample with Amritikarana. Conclusion From the present study, it is concluded that TB with Amritikarana was found to be relatively safer than TB without Amritikarana at different dose levels in rats and hence suggest for safely use in humans at therapeutic dose level. It proves the role of Amritikarana in the preparation of TB.

Original languageEnglish
Pages (from-to)23-29
Number of pages7
JournalJournal of Ayurveda and Integrative Medicine
Volume7
Issue number1
DOIs
StatePublished - 1 Jan 2016
Externally publishedYes

Keywords

  • Acute toxicity
  • Amritikarana
  • Shodhana
  • Subchronic toxicity
  • Tamra Bhasma

ASJC Scopus subject areas

  • Drug Discovery
  • Complementary and alternative medicine

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