Acute Generalized Exanthematous Pustulosis

Sima Halevy

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


    Acute generalized exanthematous pustulosis (AGEP) is a rare, severe, pustular reaction pattern, attributed mainly to drugs. Other triggers such as infections, spider bite, and contact sensitivity have been implicated. AGEP is characterized by typical morphology, unique histology, and a rapid clinical course. The AGEP validation score (EuroSCAR group criteria) is a useful tool for establishing the diagnosis. The immune pathogenesis involves drug-specific T-cells, neutrophils, and the release of cytokines/chemokines (i.e., IL-8/CXCL8). In view of the remarkable clinical and histological similarity between AGEP and pustular psoriasis, the genetic basis of AGEP should be further evaluated.

    Original languageEnglish
    Title of host publicationAdvances in Diagnosis and Management of Cutaneous Adverse Drug Reactions
    Subtitle of host publicationCurrent and Future Trends
    PublisherSpringer Singapore
    Number of pages18
    ISBN (Electronic)9789811314896
    ISBN (Print)9789811314889
    StatePublished - 1 Jan 2018


    • Acute generalized exanthematous pustulosis
    • Adverse reaction
    • Cytokines
    • Generalized pustular psoriasis
    • Pustular drug eruption
    • T-cells

    ASJC Scopus subject areas

    • General Medicine
    • Pharmacology, Toxicology and Pharmaceutics (all)


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