Acute Generalized Exanthematous Pustulosis

Sima Halevy

doi:10.1007/978-981-13-1489-6_8

Acute Generalized Exanthematous Pustulosis

Sima Halevy

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

Acute generalized exanthematous pustulosis (AGEP) is a rare, severe, pustular reaction pattern, attributed mainly to drugs. Other triggers such as infections, spider bite, and contact sensitivity have been implicated. AGEP is characterized by typical morphology, unique histology, and a rapid clinical course. The AGEP validation score (EuroSCAR group criteria) is a useful tool for establishing the diagnosis. The immune pathogenesis involves drug-specific T-cells, neutrophils, and the release of cytokines/chemokines (i.e., IL-8/CXCL8). In view of the remarkable clinical and histological similarity between AGEP and pustular psoriasis, the genetic basis of AGEP should be further evaluated.

Original language	English
Title of host publication	Advances in Diagnosis and Management of Cutaneous Adverse Drug Reactions
Subtitle of host publication	Current and Future Trends
Publisher	Springer Singapore
Pages	105-122
Number of pages	18
ISBN (Electronic)	9789811314896
ISBN (Print)	9789811314889
DOIs	https://doi.org/10.1007/978-981-13-1489-6_8
State	Published - 1 Jan 2018

Keywords

Acute generalized exanthematous pustulosis
Adverse reaction
Cytokines
Generalized pustular psoriasis
Pustular drug eruption
T-cells

ASJC Scopus subject areas

General Medicine
General Pharmacology, Toxicology and Pharmaceutics

Access to Document

10.1007/978-981-13-1489-6_8

Cite this

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KW - Adverse reaction

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Acute Generalized Exanthematous Pustulosis

Abstract

Keywords

ASJC Scopus subject areas

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