Abstract
Seven- and 10-membered cyclic thioenamino peptides, that is, 1,4-thiazepinone (11) and cyclic thioenamino peptide 9 (which represents a potential γ-turn mimetic), were synthesized, and the structure of 11 was secured by X-ray diffraction analysis of its TFA salt. The aforementioned compounds were prepared in solution and by solid-phase synthesis. Additionally, we have prepared thioenamino diketopiperazine synthon 16.
Original language | English |
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Pages (from-to) | 1048-1050 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 50 |
Issue number | 9 |
DOIs | |
State | Published - 4 Mar 2009 |
Externally published | Yes |
Keywords
- Cyclic peptides
- Endiamine
- FGly
- Solid-phase synthesis
- Thioenamine
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry