Adaptive doses of irradiation - An approach to a new therapy concept for bladder cancer?

Moshe Schaffer, Silke B. Schwarz, Ulrike Kulka, Martin Busch, Eckhart Dühmke

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Radiation adaptive response in terms of induced radioresistance or hyperradiosensitivity, has been studied in HCV29 (human bladder epithelium) and RT4 (human bladder carcinoma) cell lines. After pre-irradiation doses of 0.05 Gy or 0.1 Gy, HCV29 cells showed induced radioresistance, whereas after pre-irradiation doses of 0.05 Gy, 0.1 Gy, 0.2 Gy, and 0.5 Gy, the RT4 cells clearly showed hyperradiosensitivity. On the basis of these results, an approach has been developed that may lead to a concept for a new radiotherapeutic regimen of bladder cancer that includes protection of normal cells, on the one hand, and the potential of tumor cell damage, on the other hand. These findings need to be confirmed in further studies for the benefit of the patients.

Original languageEnglish
Pages (from-to)271-276
Number of pages6
JournalRadiation and Environmental Biophysics
Volume43
Issue number4
DOIs
StatePublished - 1 Dec 2004
Externally publishedYes

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