TY - JOUR
T1 - Add-on deep Transcranial Magnetic Stimulation (dTMS) for the treatment of chronic migraine
T2 - A preliminary study
AU - Rapinesi, Chiara
AU - Del Casale, Antonio
AU - Scatena, Paola
AU - Kotzalidis, Georgios D.
AU - Di Pietro, Simone
AU - Ferri, Vittoria Rachele
AU - Bersani, Francesco Saverio
AU - Brugnoli, Roberto
AU - Raccah, Ruggero Nessim
AU - Zangen, Abraham
AU - Ferracuti, Stefano
AU - Orzi, Francesco
AU - Girardi, Paolo
AU - Sette, Giuliano
N1 - Publisher Copyright:
© 2016
PY - 2016/6/3
Y1 - 2016/6/3
N2 - Introduction Deep Transcranial Magnetic Stimulation (dTMS) can be an alternative treatment to relieve pain in chronic migraine (CM). The aim of this study was to evaluate the effect of high-frequency dTMS in add-on to standard treatment for CM in patients not responding to effective abortive or preventive drug treatment. Methods We randomized 14 patients with International Classification of Headache Disorders, 3rd Edition (ICHD-3) treatment-resistant CM to add-on dTMS (n = 7) or standard abortive or preventive antimigraine treatment (n = 7). Three sessions of alternate day 10 Hz dTMS consisting of 600 pulses in 10 trains were delivered to the dorsolateral prefrontal cortex (DLPFC), bilaterally, but with left hemisphere prevalence, for 12 sessions spread over one month. Results The add-on dTMS treatment was well tolerated. Patients treated with dTMS showed significant reduction of pain intensity, frequency of attacks, analgesic overuse, and depressive symptoms during treatment and one month later, compared to the month preceding treatment and at the same time-points compared to the control group. Conclusions As compared to standard pharmacological treatment alone, add-on high-frequency dTMS of the bilateral DLPFC reduced the frequency and intensity of migraine attack, drug overuse, and depressive symptoms. This study supports the add-on dTMS treatment in treatment-resistant CM.
AB - Introduction Deep Transcranial Magnetic Stimulation (dTMS) can be an alternative treatment to relieve pain in chronic migraine (CM). The aim of this study was to evaluate the effect of high-frequency dTMS in add-on to standard treatment for CM in patients not responding to effective abortive or preventive drug treatment. Methods We randomized 14 patients with International Classification of Headache Disorders, 3rd Edition (ICHD-3) treatment-resistant CM to add-on dTMS (n = 7) or standard abortive or preventive antimigraine treatment (n = 7). Three sessions of alternate day 10 Hz dTMS consisting of 600 pulses in 10 trains were delivered to the dorsolateral prefrontal cortex (DLPFC), bilaterally, but with left hemisphere prevalence, for 12 sessions spread over one month. Results The add-on dTMS treatment was well tolerated. Patients treated with dTMS showed significant reduction of pain intensity, frequency of attacks, analgesic overuse, and depressive symptoms during treatment and one month later, compared to the month preceding treatment and at the same time-points compared to the control group. Conclusions As compared to standard pharmacological treatment alone, add-on high-frequency dTMS of the bilateral DLPFC reduced the frequency and intensity of migraine attack, drug overuse, and depressive symptoms. This study supports the add-on dTMS treatment in treatment-resistant CM.
KW - Chronic migraine
KW - Deep transcranial magnetic stimulation (dTMS)
KW - Dorsolateral prefrontal cortex (DLPFC)
KW - Treatment-resistant migraine
UR - http://www.scopus.com/inward/record.url?scp=84990046454&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2016.04.058
DO - 10.1016/j.neulet.2016.04.058
M3 - Article
AN - SCOPUS:84990046454
SN - 0304-3940
VL - 623
SP - 7
EP - 12
JO - Neuroscience Letters
JF - Neuroscience Letters
ER -