Adenotonsillectomy improves slow-wave activity in children with obstructive sleep apnoea

N. Ben-Israel, Y. Zigel, A. Tal, Y. Segev, A. Tarasiuk

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

The aim of the present study was to estimate slow-wave activity (SWA), a marker of sleep homeostasis, in children with obstructive sleep apnoea (OSA) before and after adenotonsillectomy (AT) compared with untreated OSA children (comparison group). 14 children with OSA (mean±SD age 6.4±2.5 yrs; apnoea-hypopnoea index (AHI) 10.0±10.3 events·h-1) who underwent AT were consecutively recruited to the study. The comparison group comprised six retrospectively recruited children (age 5.4±2.2 yrs; AHI 9.4±7.6 events·h-1) with OSA that did not undergo treatment. Electroencephalogram (derivation C3/A2) was analysed using spectral and waveform analysis to determine SWA energy and slow-wave slope. The same procedure was repeated 5.4 and 19 months later for the AT and comparison groups, respectively. AT improved respiration without a change in duration of sleep stages. Following AT, >50% elevation of SWA during the first two sleep cycles (p<0.01) and a more physiological decay of SWA across the night (p,0.0001) were noted. The slow-wave slope increased by >30% following AT (p<0.03). No significant changes were found in SWA in the comparison group. Sleep homeostasis is considerably impaired in pre-pubescent children with OSA. AT restores more physiological sleep homeostasis in children with OSA. SWA analysis may provide a useful addition to standard sleep-stage analyses in children with OSA. Copyright

Original languageEnglish
Pages (from-to)1144-1150
Number of pages7
JournalEuropean Respiratory Journal
Volume37
Issue number5
DOIs
StatePublished - 1 May 2011

Keywords

  • Adenotonsillectomy
  • Children
  • Obstructive sleep apnoea
  • Slow-wave activity

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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