The adhesion of explosive particles to substrates with tailored chemical nature was analyzed by atomic force microscopy (AFM). Four different explosives were studied: TNT, RDX, HMX, and PETN. Two types of measurements were performed: in the first, a self-assembled monolayer (SAM) with different end groups was deposited on the tip and used to measure adhesion forces to an explosive particle surface. In the second type of experiment, the explosive particle was glued to the cantilever, and its adhesion force to a SAM-covered gold-plated glass substrate was measured. All experiments were performed both in ambient air and under water. The study shows that-OH and-C 6H 5 end groups lead to increased adhesion. In addition, we found that capillary forces have significantly contributed to the adhesion of explosive particles.