TY - JOUR
T1 - Adiponectin in amniotic fluid in normal pregnancy, spontaneous labor at term, and preterm labor
T2 - A novel association with intra-amniotic infection/inflammation
AU - Mazaki-Tovi, Shali
AU - Romero, Roberto
AU - Vaisbuch, Edi
AU - Kusanovic, Juan Pedro
AU - Erez, Offer
AU - Mittal, Pooja
AU - Gotsch, Francesca
AU - Chaiworapongsa, Tinnakorn
AU - Than, Nandor Gabor
AU - Kim, Sun Kwon
AU - Pacora, Percy
AU - Yeo, Lami
AU - Dong, Zhong
AU - Hassan, Sonia S.
N1 - Funding Information:
This work was supported by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS.
PY - 2010/2/1
Y1 - 2010/2/1
N2 - Objective.Adiponectin, an anti-inflammatory and anti-diabetogenic adipokine, has an important regulatory effect on both the innate and adaptive limbs of the immune response. The objective of this study was to determine whether adiponectin is present in amniotic fluid (AF) and if its concentration changes with gestational age, in the presence of labor, and in the presence of intra-amniotic infection (IAI) in patients with spontaneous preterm labor (PTL) and intact membranes. Study design.This cross-sectional study included 468 patients in the following groups: (1) women in the mid-trimester of pregnancy (14-18 weeks) who underwent amniocentesis for genetic indications and delivered a normal neonate at term (n=52); (2) normal pregnant women at term with (n=49) and without (n=41) spontaneous labor; (3) patients with an episode of PTL and intact membranes who were classified into: (a) PTL who delivered at term (n=149); (b) PTL who delivered preterm (<37 weeks gestation) without IAI (n=108); and (c) PTL with IAI (n=69). Adiponectin concentration in AF was determined by ELISA. Results.(1) The median AF adiponectin concentration at term was significantly higher than in the mid-trimester (35.6ng/ml, interquartile range [IQR] 26.4-52.7 vs. 29.9ng/ml, IQR 19.9-35.2; p=0.01); (2) among women with PTL and intact membranes, the median AF adiponectin concentration was significantly higher in patients with IAI than in those without IAI who delivered either at term (54.3ng/ml, 39.0-91.8 vs. 50.1ng/ml, 33.2-72.8; p=0.02) or preterm (47.6ng/ml, 32.6-74.6; p=0.01); and (3) among women at term, there was no significant difference in the median AF adiponectin concentration between those with and without labor (33.7ng/ml, IQR 21.7-53.9 vs. 35.6ng/ml, IQR 26.4-52.7; respectively p=0.5). Conclusions.(1) Adiponectin is a physiologic constituent of AF; and (2) adiponectin concentrations in AF are increased significantly with advancing gestation and in the presence of IAI. Collectively, these findings suggest that adiponectin plays a dynamic role in normal gestation and in the presence of IAI.
AB - Objective.Adiponectin, an anti-inflammatory and anti-diabetogenic adipokine, has an important regulatory effect on both the innate and adaptive limbs of the immune response. The objective of this study was to determine whether adiponectin is present in amniotic fluid (AF) and if its concentration changes with gestational age, in the presence of labor, and in the presence of intra-amniotic infection (IAI) in patients with spontaneous preterm labor (PTL) and intact membranes. Study design.This cross-sectional study included 468 patients in the following groups: (1) women in the mid-trimester of pregnancy (14-18 weeks) who underwent amniocentesis for genetic indications and delivered a normal neonate at term (n=52); (2) normal pregnant women at term with (n=49) and without (n=41) spontaneous labor; (3) patients with an episode of PTL and intact membranes who were classified into: (a) PTL who delivered at term (n=149); (b) PTL who delivered preterm (<37 weeks gestation) without IAI (n=108); and (c) PTL with IAI (n=69). Adiponectin concentration in AF was determined by ELISA. Results.(1) The median AF adiponectin concentration at term was significantly higher than in the mid-trimester (35.6ng/ml, interquartile range [IQR] 26.4-52.7 vs. 29.9ng/ml, IQR 19.9-35.2; p=0.01); (2) among women with PTL and intact membranes, the median AF adiponectin concentration was significantly higher in patients with IAI than in those without IAI who delivered either at term (54.3ng/ml, 39.0-91.8 vs. 50.1ng/ml, 33.2-72.8; p=0.02) or preterm (47.6ng/ml, 32.6-74.6; p=0.01); and (3) among women at term, there was no significant difference in the median AF adiponectin concentration between those with and without labor (33.7ng/ml, IQR 21.7-53.9 vs. 35.6ng/ml, IQR 26.4-52.7; respectively p=0.5). Conclusions.(1) Adiponectin is a physiologic constituent of AF; and (2) adiponectin concentrations in AF are increased significantly with advancing gestation and in the presence of IAI. Collectively, these findings suggest that adiponectin plays a dynamic role in normal gestation and in the presence of IAI.
KW - Adipokines
KW - Adiponectin
KW - Chorioamnionitis
KW - Inflammation
KW - Intra-amniotic infection
KW - Pregnancy
KW - Preterm birth
KW - Preterm delivery
KW - Preterm labor
UR - http://www.scopus.com/inward/record.url?scp=75449100965&partnerID=8YFLogxK
U2 - 10.3109/14767050903026481
DO - 10.3109/14767050903026481
M3 - Article
AN - SCOPUS:75449100965
SN - 1476-7058
VL - 23
SP - 120
EP - 130
JO - Journal of Maternal-Fetal and Neonatal Medicine
JF - Journal of Maternal-Fetal and Neonatal Medicine
IS - 2
ER -