Adiponectin in severe preeclampsia

Jyh Kae Nien, Shali Mazaki-Tovi, Roberto Romero, Offer Erez, Juan Pedro Kusanovic, Francesca Gotsch, Beth L. Pineles, Ricardo Gomez, Samuel Edwin, Moshe Mazor, Jimmy Espinoza, Bo Hyun Yoon, Sonia S. Hassan

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


Aims: Adiponectin is an adipokine with insulin-sensitizing, anti-atherogenic, anti-inflammatory and angiogenic properties. The aims of this study were to determine whether maternal plasma adiponectin concentrations differ between patients with severe preeclampsia and those with normal pregnancies, and to explore the relationship between plasma adiponectin and the results of Doppler velocimetry of the uterine arteries. Methods: This case-control study included two groups: (1) patients with severe preeclampsia (n=50) and (2) patients with normal pregnancies (n=150). Pulsed-wave and color Doppler ultrasound examination of the uterine arteries were performed. Plasma adiponectin concentrations were determined by ELISA. Non-parametric statistics were used for analysis. Results: (1) Patients with severe preeclampsia had a higher median plasma concentration of adiponectin than that of normal pregnant women. (2) The median plasma adiponectin concentration did not differ between women with severe preeclampsia who had a high impedance to blood flow in the uterine arteries and those with normal impedance to blood flow. (3) Among patients with normal pregnancies, plasma adiponectin concentrations were negatively correlated with BMI in the first trimester and at sampling. Conclusions: Women with severe preeclampsia have a higher median plasma concentration of adiponectin than that of normal pregnant women. This may reflect a compensatory feedback mechanism to the metabolically-altered, anti-angiogenic and pro-atherogenic state of severe preeclampsia.

Original languageEnglish
Pages (from-to)503-512
Number of pages10
JournalJournal of Perinatal Medicine
Issue number6
StatePublished - 1 Dec 2007
Externally publishedYes


  • Adiponectin
  • Doppler
  • Obesity
  • Preeclampsia
  • Pregnancy
  • Uterine artery

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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