Adipose stress-sensing kinases: linking obesity to malfunction

Assaf Rudich, Hannah Kanety, Nava Bashan

Research output: Contribution to journalReview articlepeer-review

62 Scopus citations

Abstract

Obesity has been proposed to inflict a variety of stresses on adipose tissue, including inflammatory, metabolic, oxidative and endoplasmic reticulum stress. Through the activation of 'stress-sensing pathways', metabolic and endocrine alterations are produced, which probably contribute to the co-morbidities associated with obesity. Here, we review the evidence supporting the development of various obesity-related stresses and the activation of several stress-sensing pathways, specifically in adipocytes and/or adipose tissue, which manifest metabolic and endocrine dysfunction frequently in obesity. As the central role of adipose tissue in regulating whole-body metabolism is elucidated, understanding adipose tissue stress-sensing pathways might provide potential new therapeutic targets to attenuate obesity-related morbidity.

Original languageEnglish
Pages (from-to)291-299
Number of pages9
JournalTrends in Endocrinology and Metabolism
Volume18
Issue number8
DOIs
StatePublished - 1 Oct 2007

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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