Administration, distribution, metabolism and elimination of polymer therapeutics

Ela Markovsky; Hemda Baabur-Cohen; Anat Eldar-Boock; Liora Omer; Galia Tiram; Shiran Ferber; Paula Ofek; Dina Polyak; Anna Scomparin; Ronit Satchi-Fainaro

doi:10.1016/j.jconrel.2011.12.021

Administration, distribution, metabolism and elimination of polymer therapeutics

Ela Markovsky
, Hemda Baabur-Cohen
, Anat Eldar-Boock
, Liora Omer
, Galia Tiram
, Shiran Ferber
, Paula Ofek
, Dina Polyak
, Anna Scomparin
, Ronit Satchi-Fainaro

Research output: Contribution to journal › Review article › peer-review

291 Scopus citations

Abstract

Polymer conjugation is an efficient approach to improve the delivery of drugs and biological agents, both by protecting the body from the drug (by improving biodistribution and reducing toxicity) and by protecting the drug from the body (by preventing degradation and enhancing cellular uptake). This review discusses the journey that polymer therapeutics make through the body, following the ADME (absorption, distribution, metabolism, excretion) concept. The biological factors and delivery system parameters that influence each stage of the process will be described, with examples illustrating the different solutions to the challenges of drug delivery systems in vivo.

Original language	English
Pages (from-to)	446-460
Number of pages	15
Journal	Journal of Controlled Release
Volume	161
Issue number	2
DOIs	https://doi.org/10.1016/j.jconrel.2011.12.021
State	Published - 20 Jul 2012
Externally published	Yes

Keywords

ADME
Angiogenesis
Angiogenesis- dependent diseases
Biodistribution
Cancer
Polymer therapeutics

ASJC Scopus subject areas

Pharmaceutical Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jconrel.2011.12.021

Cite this

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title = "Administration, distribution, metabolism and elimination of polymer therapeutics",

abstract = "Polymer conjugation is an efficient approach to improve the delivery of drugs and biological agents, both by protecting the body from the drug (by improving biodistribution and reducing toxicity) and by protecting the drug from the body (by preventing degradation and enhancing cellular uptake). This review discusses the journey that polymer therapeutics make through the body, following the ADME (absorption, distribution, metabolism, excretion) concept. The biological factors and delivery system parameters that influence each stage of the process will be described, with examples illustrating the different solutions to the challenges of drug delivery systems in vivo.",

keywords = "ADME, Angiogenesis, Angiogenesis- dependent diseases, Biodistribution, Cancer, Polymer therapeutics",

author = "Ela Markovsky and Hemda Baabur-Cohen and Anat Eldar-Boock and Liora Omer and Galia Tiram and Shiran Ferber and Paula Ofek and Dina Polyak and Anna Scomparin and Ronit Satchi-Fainaro",

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AU - Markovsky, Ela

AU - Baabur-Cohen, Hemda

AU - Eldar-Boock, Anat

AU - Omer, Liora

AU - Tiram, Galia

AU - Ferber, Shiran

AU - Ofek, Paula

AU - Polyak, Dina

AU - Scomparin, Anna

AU - Satchi-Fainaro, Ronit

PY - 2012/7/20

Y1 - 2012/7/20

N2 - Polymer conjugation is an efficient approach to improve the delivery of drugs and biological agents, both by protecting the body from the drug (by improving biodistribution and reducing toxicity) and by protecting the drug from the body (by preventing degradation and enhancing cellular uptake). This review discusses the journey that polymer therapeutics make through the body, following the ADME (absorption, distribution, metabolism, excretion) concept. The biological factors and delivery system parameters that influence each stage of the process will be described, with examples illustrating the different solutions to the challenges of drug delivery systems in vivo.

AB - Polymer conjugation is an efficient approach to improve the delivery of drugs and biological agents, both by protecting the body from the drug (by improving biodistribution and reducing toxicity) and by protecting the drug from the body (by preventing degradation and enhancing cellular uptake). This review discusses the journey that polymer therapeutics make through the body, following the ADME (absorption, distribution, metabolism, excretion) concept. The biological factors and delivery system parameters that influence each stage of the process will be described, with examples illustrating the different solutions to the challenges of drug delivery systems in vivo.

KW - ADME

KW - Angiogenesis

KW - Angiogenesis- dependent diseases

KW - Biodistribution

KW - Cancer

KW - Polymer therapeutics

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U2 - 10.1016/j.jconrel.2011.12.021

DO - 10.1016/j.jconrel.2011.12.021

M3 - Review article

C2 - 22286005

AN - SCOPUS:84862675929

SN - 0168-3659

VL - 161

SP - 446

EP - 460

JO - Journal of Controlled Release

JF - Journal of Controlled Release

IS - 2

ER -

Administration, distribution, metabolism and elimination of polymer therapeutics

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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