Adriamycin Inhibits the B to Z Transition of Poly(dGm5dC)·Poly(dGm5dC)

Chi wan Chen; Jack S. Cohen; Richard H. Knop

doi:10.1021/bi00293a002

Adriamycin Inhibits the B to Z Transition of Poly(dGm⁵dC)·Poly(dGm⁵dC)

Chi wan Chen, Jack S. Cohen, Richard H. Knop

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30 Scopus citations

Abstract

Adriamycin inhibits the Mg²⁺-induced B to Z conformational transition of poly(dGm⁵dC)·poly(dGm⁵dC) and reduces the degree of cooperativity of the transition. Additionally, adriamycin alone converts the Z-form to the B-form in a cooperative manner. These results indicate that adriamycin binds preferentially to the B-form, which could be relevant to its mode of cytotoxic action.

Original language	English
Pages (from-to)	5468-5471
Number of pages	4
Journal	Biochemistry
Volume	22
Issue number	24
DOIs	https://doi.org/10.1021/bi00293a002
State	Published - 1 Jan 1983
Externally published	Yes

ASJC Scopus subject areas

Biochemistry

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10.1021/bi00293a002

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title = "Adriamycin Inhibits the B to Z Transition of Poly(dGm5dC)·Poly(dGm5dC)",

abstract = "Adriamycin inhibits the Mg2+-induced B to Z conformational transition of poly(dGm5dC)·poly(dGm5dC) and reduces the degree of cooperativity of the transition. Additionally, adriamycin alone converts the Z-form to the B-form in a cooperative manner. These results indicate that adriamycin binds preferentially to the B-form, which could be relevant to its mode of cytotoxic action.",

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AU - Cohen, Jack S.

AU - Knop, Richard H.

PY - 1983/1/1

Y1 - 1983/1/1

N2 - Adriamycin inhibits the Mg2+-induced B to Z conformational transition of poly(dGm5dC)·poly(dGm5dC) and reduces the degree of cooperativity of the transition. Additionally, adriamycin alone converts the Z-form to the B-form in a cooperative manner. These results indicate that adriamycin binds preferentially to the B-form, which could be relevant to its mode of cytotoxic action.

AB - Adriamycin inhibits the Mg2+-induced B to Z conformational transition of poly(dGm5dC)·poly(dGm5dC) and reduces the degree of cooperativity of the transition. Additionally, adriamycin alone converts the Z-form to the B-form in a cooperative manner. These results indicate that adriamycin binds preferentially to the B-form, which could be relevant to its mode of cytotoxic action.

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Adriamycin Inhibits the B to Z Transition of Poly(dGm⁵dC)·Poly(dGm⁵dC)

Abstract

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