Adult infection with hepatitis A despite declining endemicity; in favor of adult vaccination

David Gillis, Itamar Grotto, Daniel Mimouni, Michael Huerta, Michael Gdalevich, Ofer Shpilberg

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Seropositivity against hepatitis A was examined among 4806 standing army personnel (4497 males and 309 females) during 1998-1999. Each bi-annual birth cohort examined showed a decline in seropositivity compared to the previous one. When compared with a study performed in 1989, however, for each of the 1961-1962, 1963-1964, 1965-1966, 1967-1968 and 1969-1970 birth cohorts examined, the 1998-1999 study showed 5-15% higher seropositivity. This trend remained after controlling for differences between the two studies in ethnic origin, sibship size and level of education. The overall seroconversion rate is estimated as 1.15% per year and the clinical to subclinical ratio as 1:14. Thus, hepatitis A infection continues to occur in the young adult age group and vaccination of this group should be considered.

Original languageEnglish
Pages (from-to)2243-2248
Number of pages6
JournalVaccine
Volume20
Issue number17-18
DOIs
StatePublished - 22 May 2002
Externally publishedYes

Keywords

  • Birth cohort
  • Hepatitis A
  • Immunity
  • Seropositivity
  • Vaccination

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology (all)
  • Veterinary (all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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