Advanced materials and devices for the regulation and study of NK cells

Guillaume Le Saux, Mark Schvartzman

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Natural Killer (NK) cells are innate lymphocytes that contribute to immune protection by cytosis, cytokine secretion, and regulation of adaptive responses of T cells. NK cells distinguish between healthy and ill cells, and generate a cytotoxic response, being cumulatively regulated by environmental signals delivered through their diverse receptors. Recent advances in biomaterials and device engineering paved the way to numerous artificial microenvironments for cells, which produce synthetic signals identical or similar to those provided by the physiological environment. In this paper, we review recent advances in materials and devices for artificial signaling, which have been applied to regulate NK cells, and systematically study the role of these signals in NK cell function.

Original languageEnglish
Article number646
JournalInternational Journal of Molecular Sciences
Volume20
Issue number3
DOIs
StatePublished - 1 Feb 2019

Keywords

  • Artificial immune synapse
  • Biomaterials
  • Immune signaling
  • NK cells
  • Nanodevices

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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