TY - JOUR
T1 - Advancements and future directions in research of the roles of insulin in amyloid diseases
AU - Miller, Yifat
N1 - Funding Information:
This work was supported by the Israel Science Foundation (Grant 532/15 ). All the simulations that are presented in this review were performed using the high-performance computational facilities of the Miller lab in the BGU HPC computational center. The support of the BGU HPC computational center staff is greatly appreciated.
Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2022/2/1
Y1 - 2022/2/1
N2 - Amyloid diseases, such as type 2 diabetes, Alzheimer's disease and Parkinson's disease are characterized by amyloid aggregates. Insulin is released from the pancreas, and it is known that insulin downstream signaling molecules are located majorly in the regions of cortex and hippocampus. Therefore, insulin plays crucial roles not only in the pancreas, but also in the brain. Recent studies have focused on the role of insulin in amyloid diseases. This review demonstrates the recent studies in which insulin affects amyloid aggregation. Specifically, molecular modeling studies provide insights into the molecular mechanisms of the effects of insulin in amyloid aggregates. Still, experimental studies are required to provide insights into the kinetics effects. This review opens new avenues for future studies on insulin molecules and amyloid aggregation.
AB - Amyloid diseases, such as type 2 diabetes, Alzheimer's disease and Parkinson's disease are characterized by amyloid aggregates. Insulin is released from the pancreas, and it is known that insulin downstream signaling molecules are located majorly in the regions of cortex and hippocampus. Therefore, insulin plays crucial roles not only in the pancreas, but also in the brain. Recent studies have focused on the role of insulin in amyloid diseases. This review demonstrates the recent studies in which insulin affects amyloid aggregation. Specifically, molecular modeling studies provide insights into the molecular mechanisms of the effects of insulin in amyloid aggregates. Still, experimental studies are required to provide insights into the kinetics effects. This review opens new avenues for future studies on insulin molecules and amyloid aggregation.
KW - Alzheimer's disease
KW - Amyloid fibrils
KW - Insulin
KW - Parkinson's disease
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85119402470&partnerID=8YFLogxK
U2 - 10.1016/j.bpc.2021.106720
DO - 10.1016/j.bpc.2021.106720
M3 - Article
C2 - 34823073
AN - SCOPUS:85119402470
SN - 0301-4622
VL - 281
JO - Biophysical Chemistry
JF - Biophysical Chemistry
M1 - 106720
ER -
