TY - JOUR
T1 - Aerosolized hyaluronic acid decorated, ferulic acid loaded chitosan nanoparticle
T2 - A promising asthma control strategy
AU - Dhayanandamoorthy, Yamini
AU - Antoniraj, M. Gover
AU - Kandregula, Chaya A.Babu
AU - Kandasamy, Ruckmani
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/12/15
Y1 - 2020/12/15
N2 - Vibrating mesh nebulizers are recognized as the most efficient actuation technique over conventional inhalers for drug deposition. This study explored hyaluronic acid (HA) decorated, ferulic acid (FA) loaded chitosan (CS) nanoparticle (FACHA) aerosolized using vibrating mesh nebulizer as strategic combination of drug, nanocarrier and delivery device for effective asthma control. FACHA exhibited spherical morphology with suitable size (164.2 ± 9.7 nm), zeta potential (24.0 ± 0.5 mV), entrapment efficiency (EE%) (65.0 ± 1.5), loading capacity (LC%) (18.5 ± 0.4) and mass median aerodynamic diameter (MMAD) of 1.81 ± 0.15 µm, ascertaining efficient drug deposition. In vivo inhalation toxicity assessment confirmed safety, while, FACHA prophylaxis mitigated inflammation, airway hypersensitivity and remodelling in ovalbumin (OVA) induced mice models. The results thus accentuated the role of pro-pulmonary surface chemistry conferred by HA functionalization that improved 1) thermal stability (thermogravimetric analysis - TGA) and 2) therapeutic efficacy of FA, by facilitating better interaction and transportation across mucus barrier, which otherwise suffers poor bioavailability and rapid metabolism.
AB - Vibrating mesh nebulizers are recognized as the most efficient actuation technique over conventional inhalers for drug deposition. This study explored hyaluronic acid (HA) decorated, ferulic acid (FA) loaded chitosan (CS) nanoparticle (FACHA) aerosolized using vibrating mesh nebulizer as strategic combination of drug, nanocarrier and delivery device for effective asthma control. FACHA exhibited spherical morphology with suitable size (164.2 ± 9.7 nm), zeta potential (24.0 ± 0.5 mV), entrapment efficiency (EE%) (65.0 ± 1.5), loading capacity (LC%) (18.5 ± 0.4) and mass median aerodynamic diameter (MMAD) of 1.81 ± 0.15 µm, ascertaining efficient drug deposition. In vivo inhalation toxicity assessment confirmed safety, while, FACHA prophylaxis mitigated inflammation, airway hypersensitivity and remodelling in ovalbumin (OVA) induced mice models. The results thus accentuated the role of pro-pulmonary surface chemistry conferred by HA functionalization that improved 1) thermal stability (thermogravimetric analysis - TGA) and 2) therapeutic efficacy of FA, by facilitating better interaction and transportation across mucus barrier, which otherwise suffers poor bioavailability and rapid metabolism.
KW - Aerosol
KW - Asthma control therapy
KW - Chitosan
KW - Chitosan nanoparticles
KW - Ferulic acid
KW - Hyaluronic acid
KW - Hyaluronic acid functionalization
KW - Inhalation toxicity
KW - Methacholine
KW - Ovalbumin
KW - Pulmonary drug delivery
KW - Sodium tripolyphosphate
UR - http://www.scopus.com/inward/record.url?scp=85094843693&partnerID=8YFLogxK
U2 - 10.1016/j.ijpharm.2020.119958
DO - 10.1016/j.ijpharm.2020.119958
M3 - Article
C2 - 33148522
AN - SCOPUS:85094843693
SN - 0378-5173
VL - 591
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
M1 - 119958
ER -