Age Differences in Recovery Rate Following an Aerobic-Based Exercise Protocol Inducing Muscle Damage Among Amateur, Male Athletes

Irit Markus, Keren Constantini, Nir Goldstein, Roee Amedi, Yael Bornstein, Yael Stolkovsky, Merav Vidal, Shahar Lev-Ari, Roy Balaban, Stav Leibou, Tamar Blumenfeld-Katzir, Noam Ben-Eliezer, David Peled, Yaniv Assaf, Dennis Jensen, Naama Constantini, Gal Dubnov-Raz, Israel Halperin, Yftach Gepner

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Purpose: Compare recovery rates between active young (Y) and middle-aged (MA) males up to 48H post aerobically based, exercise-induced muscle damage (EIMD) protocol. A secondary aim was to explore the relationships between changes in indices associated with EIMD and recovery throughout this timeframe. Methods: Twenty-eight Y (n = 14, 26.1 ± 2.9y, 74.5 ± 9.3 kg) and MA (n = 14, 43.6 ± 4.1y, 77.3 ± 12.9 kg) physically active males, completed a 60-min downhill running (DHR) on a treadmill at −10% incline and at 65% of maximal heart rate (HR). Biochemical, biomechanical, psychological, force production and muscle integrity (using MRI diffusion tensor imaging) markers were measured at baseline, immediately-post, and up to 48H post DHR. Results: During the DHR, HR was lower (p < 0.05) in MA compared to Y, but running pace and distance covered were comparable between groups. No statistical or meaningful differences were observed between groups for any of the outcomes. Yet, Significant (p < 0.05) time-effects within each group were observed: markers of muscle damage, cadence and perception of pain increased, while TNF-a, isometric and dynamic force production and stride-length decreased. Creatine-kinase at 24H-post and 48H-post were correlated (p < 0.05, r range = −0.57 to 0.55) with pain perception, stride-length, and cadence at 24H-post and 48H-post. Significant (p < 0.05) correlations were observed between isometric force production at all time-points and IL-6 at 48H-post DHR (r range = −0.62 to (−0.74). Conclusion: Y and MA active male amateur athletes recover in a comparable manner following an EIMD downhill protocol. These results indicate that similar recovery strategies can be used by trainees from both age groups following an aerobic-based EIMD protocol.

Original languageEnglish
Article number916924
JournalFrontiers in Physiology
StatePublished - 13 Jun 2022
Externally publishedYes


  • aging
  • downhill running
  • inflammation
  • muscle damage
  • pain perception
  • recovery

ASJC Scopus subject areas

  • Physiology (medical)
  • Physiology


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