TY - JOUR
T1 - Age modulates the association of caffeine intake with cognition and with gray matter in elderly diabetics
AU - West, Rebecca K.
AU - Ravona-Springer, Ramit
AU - Livny, Abigail
AU - Heymann, Anthony
AU - Shahar, Danit
AU - Leroith, Derek
AU - Preiss, Rachel
AU - Zukran, Ruth
AU - Silverman, Jeremy M.
AU - Schnaider-Beeri, Michal
N1 - Publisher Copyright:
© The Author(s) 2018. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved.
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Background: The association between caffeine and cognitive performance has not been tested in older individuals with type 2 diabetes (T2D). Its association with brain volume in T2D has been tested only in animals. Methods: We examined the association of caffeine with cognitive function and brain volume in a sample of elderly diabetics participating in the Israel Diabetes and Cognitive Decline Study (n = 638) and the moderating effect of age on this association. In a subsample (n = 185) with magnetic resonance imaging, we also examined these associations with gray and white matter volumes (GM/WM). Results: Using linear regression adjusting for cognition-related covariates, we found that higher caffeine intake was associated with better function in overall cognition (p =.018), attention/working memory (p =.002), executive functioning (p =.047), and semantic categorization (p =.026). Interaction analyses of caffeine intake with age were significant for semantic categorization (p =.025), and approached significance for overall cognition (p =.066). This association was driven by the older group (above-median) for whom the association of caffeine intake with semantic categorization (p =.001), attention/working memory (p =.007), executive functioning (p =.005), and overall cognition (p =.002) were significant. In the magnetic resonance imaging subsample, there was an interaction (p =.034) of caffeine intake with age for GM volume; in the older group, higher caffeine intake was associated with greater GM volume (β =.198, p =.033). Conclusions: Caffeine intake may have a beneficial role in cognitive functioning of elderly adults with T2D, which may be moderated by age. Greater GM volume may be a mechanism underlying the association of higher caffeine intake with better cognitive function.
AB - Background: The association between caffeine and cognitive performance has not been tested in older individuals with type 2 diabetes (T2D). Its association with brain volume in T2D has been tested only in animals. Methods: We examined the association of caffeine with cognitive function and brain volume in a sample of elderly diabetics participating in the Israel Diabetes and Cognitive Decline Study (n = 638) and the moderating effect of age on this association. In a subsample (n = 185) with magnetic resonance imaging, we also examined these associations with gray and white matter volumes (GM/WM). Results: Using linear regression adjusting for cognition-related covariates, we found that higher caffeine intake was associated with better function in overall cognition (p =.018), attention/working memory (p =.002), executive functioning (p =.047), and semantic categorization (p =.026). Interaction analyses of caffeine intake with age were significant for semantic categorization (p =.025), and approached significance for overall cognition (p =.066). This association was driven by the older group (above-median) for whom the association of caffeine intake with semantic categorization (p =.001), attention/working memory (p =.007), executive functioning (p =.005), and overall cognition (p =.002) were significant. In the magnetic resonance imaging subsample, there was an interaction (p =.034) of caffeine intake with age for GM volume; in the older group, higher caffeine intake was associated with greater GM volume (β =.198, p =.033). Conclusions: Caffeine intake may have a beneficial role in cognitive functioning of elderly adults with T2D, which may be moderated by age. Greater GM volume may be a mechanism underlying the association of higher caffeine intake with better cognitive function.
KW - Alzheimer's
KW - Cognitive aging
KW - Neuroimaging
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85067561618&partnerID=8YFLogxK
U2 - 10.1093/gerona/gly090
DO - 10.1093/gerona/gly090
M3 - Article
AN - SCOPUS:85067561618
SN - 1079-5006
VL - 74
SP - 683
EP - 688
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 5
ER -