TY - JOUR
T1 - Ageing and the mismatch repair system
AU - Yehuda, Arie Ben
AU - Globerson, Amiela
AU - Krichevsky, Svetlana
AU - Bar On, Hanoch
AU - Kidron, Miriam
AU - Friedlander, Yechiel
AU - Friedman, Gideon
AU - Ben Yehuda, Dina
N1 - Funding Information:
Original experiments were supported by grants from the Israel Cancer Association (Dina Ben Yehuda) and the Rich Foundation (Dina Ben Yehuda). Amiela Globerson is the incumbent of the Harriet and Harold Brady Chair for Cancer Research.
PY - 2001/1/20
Y1 - 2001/1/20
N2 - Age-related accumulation of mutations has been extensively documented, and it has been proposed as one of the prominent causes of malignancies in old age. The present review is focused on the particular case of DNA mismatch repair system (MMR), that has drawn increased attention for its possible relevance to malignancy. We also report on our own observations on an age-associated genomic instability that develops with age in the MMR system. Our study was performed on DNA samples that were prepared from peripheral blood cells, obtained at a 10-year interval from young and old human subjects. The two DNA samples from each individual were examined comparatively. The older individuals showed a significantly higher rate of microsatellite instability (MSI) in several loci examined, whereas no difference was found between the paired samples of any of the young subjects. We suggest that this increase in MSI with age may indicate an overall genomic instability in the elderly.
AB - Age-related accumulation of mutations has been extensively documented, and it has been proposed as one of the prominent causes of malignancies in old age. The present review is focused on the particular case of DNA mismatch repair system (MMR), that has drawn increased attention for its possible relevance to malignancy. We also report on our own observations on an age-associated genomic instability that develops with age in the MMR system. Our study was performed on DNA samples that were prepared from peripheral blood cells, obtained at a 10-year interval from young and old human subjects. The two DNA samples from each individual were examined comparatively. The older individuals showed a significantly higher rate of microsatellite instability (MSI) in several loci examined, whereas no difference was found between the paired samples of any of the young subjects. We suggest that this increase in MSI with age may indicate an overall genomic instability in the elderly.
KW - Aging
KW - Microsatellite instability (MSI)
KW - Mismatch repair (MMR)
UR - http://www.scopus.com/inward/record.url?scp=0035915787&partnerID=8YFLogxK
U2 - 10.1016/S0047-6374(00)00208-6
DO - 10.1016/S0047-6374(00)00208-6
M3 - Article
AN - SCOPUS:0035915787
SN - 0047-6374
VL - 121
SP - 173
EP - 179
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
IS - 1-3
ER -