Ageing of lymphocytes and lymphocytes in the aged

Amiela Globerson; Rita B. Effros

doi:10.1016/S0167-5699(00)01714-X

Ageing of lymphocytes and lymphocytes in the aged

Amiela Globerson, Rita B. Effros

Research output: Contribution to journal › Review article › peer-review

281 Scopus citations

Abstract

Immunosenescence is a complex process involving multiple reorganizational and developmentally regulated changes, rather than simple unidirectional decline in all functions. Here, these compensatory modulations are reviewed with reference to the importance of integrating information on cellular alterations identified in vitro with data on global physiological changes in the aged environment with which these cells interact in vivo.

Original language	English
Pages (from-to)	515-521
Number of pages	7
Journal	Immunology Today
Volume	21
Issue number	10
DOIs	https://doi.org/10.1016/S0167-5699(00)01714-X
State	Published - 30 Oct 2000
Externally published	Yes

ASJC Scopus subject areas

Immunology

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10.1016/S0167-5699(00)01714-X

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title = "Ageing of lymphocytes and lymphocytes in the aged",

abstract = "Immunosenescence is a complex process involving multiple reorganizational and developmentally regulated changes, rather than simple unidirectional decline in all functions. Here, these compensatory modulations are reviewed with reference to the importance of integrating information on cellular alterations identified in vitro with data on global physiological changes in the aged environment with which these cells interact in vivo.",

author = "Amiela Globerson and Effros, {Rita B.}",

note = "Funding Information: A.G. is the incumbent of the Harriett and Harold Brady Chair for Cancer Research. R.B.E. acknowledges the support of NIH AG10415. We gratefully acknowledge K. Lu{\textquoteright}s assistance in the preparation of Fig. 1 .",

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T1 - Ageing of lymphocytes and lymphocytes in the aged

AU - Globerson, Amiela

AU - Effros, Rita B.

N1 - Funding Information: A.G. is the incumbent of the Harriett and Harold Brady Chair for Cancer Research. R.B.E. acknowledges the support of NIH AG10415. We gratefully acknowledge K. Lu’s assistance in the preparation of Fig. 1 .

PY - 2000/10/30

Y1 - 2000/10/30

N2 - Immunosenescence is a complex process involving multiple reorganizational and developmentally regulated changes, rather than simple unidirectional decline in all functions. Here, these compensatory modulations are reviewed with reference to the importance of integrating information on cellular alterations identified in vitro with data on global physiological changes in the aged environment with which these cells interact in vivo.

AB - Immunosenescence is a complex process involving multiple reorganizational and developmentally regulated changes, rather than simple unidirectional decline in all functions. Here, these compensatory modulations are reviewed with reference to the importance of integrating information on cellular alterations identified in vitro with data on global physiological changes in the aged environment with which these cells interact in vivo.

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DO - 10.1016/S0167-5699(00)01714-X

M3 - Review article

AN - SCOPUS:0033787565

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VL - 21

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JO - Immunology Today

JF - Immunology Today

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ER -

Ageing of lymphocytes and lymphocytes in the aged

Abstract

ASJC Scopus subject areas

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