Aggressiveness of 4T1 breast cancer cells hampered by Wnt production-2 inhibitor nanoparticles: An in vitro study

Noa Ben Ghedalia-Peled, Ifat Cohen-Erez, Hanna Rapaport, Razi Vago

Research output: Contribution to journalArticlepeer-review

Abstract

Polymeric nanoparticles may enable delivery of drugs with lower systemic toxicity to solid tumors. Wnt signaling are evolutionary conserved pathways, involved in proliferation and fate decisions. Alterations in Wnt signaling play a pivotal role in various cancer types that promote cancer initiation, growth, metastasis and drug resistance. We designed a new strategy to allow an efficient targeting of both the canonical and the non-canonical Wnt pathways using nanoparticles loaded with inhibitor of Wnt productions-2 (IWP-2). This hydrophobic drug was successfully co-assembled into NPs composed of poly gamma-glutamic acid and a cationic and amphiphilic b-sheet peptide. Aggressive 4T1 breast cancer cells that were treated with IWP-2 loaded NPs gained a significant decrease in tumorigenic capacities attributed to improved IWP solubility, cellular uptake and efficacy.

Original languageEnglish
Article number120208
JournalInternational Journal of Pharmaceutics
Volume596
DOIs
StatePublished - 1 Mar 2021

Keywords

  • Breast cancer
  • Nanoparticles
  • Peptides
  • Wnt signaling

Fingerprint

Dive into the research topics of 'Aggressiveness of 4T1 breast cancer cells hampered by Wnt production-2 inhibitor nanoparticles: An in vitro study'. Together they form a unique fingerprint.

Cite this