Airway resistance measurements throughout the respiratory cycle in infants

Using a constant-volume infant whole-body plethysmograph containing a heated rebreathing bag, we have been able to measure airway resistance (R_aw) throughout the respiratory cycle using a computer-based technique. Data from the plethysmograph transducers are sampled at 60 Hz for the calculations and R_aw is calculated at each point sampled during the breath, with appropriate corrections for absolute lung volume. It was found that in most cases R_aw varied less with respect to tidal volume than to tidal flow. Various patterns of R_aw change in relation to tidal volume were found. These included an elevated but relatively constant resistance, a progressively rising expiratory resistance, and in 3 infants with laryngomalacia, a progressively rising inspiratory resistance. It was also found that the dynamic performance of the rebreathing bag was such that considerable errors would occur if apparatus resistance was assumed to be constant and so the actual apparatus resistance at each point was subtracted from the total resistance to give R_aw· In conclusion, R_aw is not constant throughout the respiratory cycle in infants and the pattern of change conveys additional information.