AKT1 E17 K pleckstrin homology domain mutation in urothelial carcinoma

Dorit E. Zilberman; Yoram Cohen; Ninette Amariglio; Edward Fridman; Jacob Ramon; Gideon Rechavi

doi:10.1016/j.cancergencyto.2009.01.009

AKT1 E17 K pleckstrin homology domain mutation in urothelial carcinoma

Dorit E. Zilberman, Yoram Cohen, Ninette Amariglio, Edward Fridman, Jacob Ramon, Gideon Rechavi

Research output: Contribution to journal › Article › peer-review

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Abstract

The PI3 K/AKT pathway is frequently activated in human cancer. Recently, a G to A point mutation (E17 K) was found in the pleckstrin homology domain of AKT1. We aimed to explore this mutation in cases of urothelial carcinoma. Using chip-based matrix-assisted laser desorption-time-of-flight (MALDI-TOF) mass spectrometer, AKT1 E17 K mutation was searched in 26 total RNA samples obtained from 26 patients known to have urothelial carcinoma. Mutation was found in one out of 26 (3.8%) patients - a 46 year old female with a low grade transitional cell carcinoma located to the lamina propria (Ta disease). Our finding is in line with previous studies showing AKT1 E17 K mutation to be rare. Yet, further studies are required to determine whether this mutation is indeed related to less aggressive disease and carries better prognosis.

Original language	English
Pages (from-to)	34-37
Number of pages	4
Journal	Cancer Genetics and Cytogenetics
Volume	191
Issue number	1
DOIs	https://doi.org/10.1016/j.cancergencyto.2009.01.009
State	Published - 1 May 2009
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cancergencyto.2009.01.009

Cite this

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title = "AKT1 E17 K pleckstrin homology domain mutation in urothelial carcinoma",

abstract = "The PI3 K/AKT pathway is frequently activated in human cancer. Recently, a G to A point mutation (E17 K) was found in the pleckstrin homology domain of AKT1. We aimed to explore this mutation in cases of urothelial carcinoma. Using chip-based matrix-assisted laser desorption-time-of-flight (MALDI-TOF) mass spectrometer, AKT1 E17 K mutation was searched in 26 total RNA samples obtained from 26 patients known to have urothelial carcinoma. Mutation was found in one out of 26 (3.8%) patients - a 46 year old female with a low grade transitional cell carcinoma located to the lamina propria (Ta disease). Our finding is in line with previous studies showing AKT1 E17 K mutation to be rare. Yet, further studies are required to determine whether this mutation is indeed related to less aggressive disease and carries better prognosis.",

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AU - Zilberman, Dorit E.

AU - Cohen, Yoram

AU - Amariglio, Ninette

AU - Fridman, Edward

AU - Ramon, Jacob

AU - Rechavi, Gideon

PY - 2009/5/1

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AB - The PI3 K/AKT pathway is frequently activated in human cancer. Recently, a G to A point mutation (E17 K) was found in the pleckstrin homology domain of AKT1. We aimed to explore this mutation in cases of urothelial carcinoma. Using chip-based matrix-assisted laser desorption-time-of-flight (MALDI-TOF) mass spectrometer, AKT1 E17 K mutation was searched in 26 total RNA samples obtained from 26 patients known to have urothelial carcinoma. Mutation was found in one out of 26 (3.8%) patients - a 46 year old female with a low grade transitional cell carcinoma located to the lamina propria (Ta disease). Our finding is in line with previous studies showing AKT1 E17 K mutation to be rare. Yet, further studies are required to determine whether this mutation is indeed related to less aggressive disease and carries better prognosis.

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AKT1 E17 K pleckstrin homology domain mutation in urothelial carcinoma

Abstract

ASJC Scopus subject areas

UN SDGs

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