TY - JOUR
T1 - Alcohol- vs hypertonic saline-assisted laser-assisted subepithelial keratectomy
AU - Hazarbassanov, Rossen
AU - Ben-Haim, Oded
AU - Varssano, David
AU - Grinbaum, Aharon
AU - Kaiserman, Igor
N1 - Funding Information:
Acknowledgment. This paper describes work partially undertaken in the context of the E-NEXT - Information Society Technologies (IST) FP6-506869 project. The IST program is partially funded by the Commission of the European Union. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the E-NEXT project. Roel Ocampo acknowledges support by the Doctoral Studies Fellowship program of the University of the Philippines.
Funding Information:
This paper describes work partially undertaken in the context of the E-NEXT - Information Society Technologies (IST) FP6-506869 project. The IST program is partially funded by the Commission of the European Union. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the E-NEXT project. Roel Ocampo acknowledges support by the Doctoral Studies Fellowship program of the University of the Philippines.
PY - 2005/2/1
Y1 - 2005/2/1
N2 - Objective: To evaluate the predictability and safety of hypertonic saline (50% sodium chloride)-assisted laser-assisted subepithelial keratectomy (HS-LASEK) vs 20% alcohol-assisted LASER (A-LASEK). Setting: American Laser Medical Center, Rishon Le-Zion, Israel. Methods: Fifty-two consecutive eyes (26 patients) were randomized to HS-LASEK (30 eyes) and A-LASEK (22 eyes) groups. The patients' eyes were examined, refracted, and photographed at 1 day, 5 days, 2 weeks, and 1 month postoperatively by a masked physician. Corneal topography and confocal examination were performed before and 1 month after surgery. Main Outcome Measures: The predictability, accuracy, and visual recovery of HS-LASEK vs A-LASEK in the first postoperative month. Results: The accuracy of HS-LASEK was similar and sometimes better than A-LASEK. Two weeks after surgery, 17 eyes (57%) in the HS-LASEK group and 10 eyes (46%) in the A-LASEK group were within ± 0.5 diopter of the intended refractive correction (P<.05). At all time points eyes in the HS-LASEK group had better best-corrected visual acuity than eyes in the A-LASEK group, although the uncorrected visual acuity was similar. Eighteen (61%) of the HS-LASEK-treated eyes and 12 (55%) of the A-LASEK-treated eyes had an epithelial defect after surgery. The HS-LASEK-treated eyes had significantly larger epithelial defects. The resolution of the defects was faster in the HS-LASEK-treated eyes (mean ± SD, 4.5 ± 0.4 days vs 5.8 ± 0.2 days, P = .002). The subepithelial scar was thicker in A-LASEK-treated eyes. Conclusions: Hypertonic saline-assisted LASEK provides good postoperative accuracy, safety, and a similar rate of complications. In view of recent evidence regarding the epithelial toxic effects of alcohol, HS-LASEK might be a better treatment alternative.
AB - Objective: To evaluate the predictability and safety of hypertonic saline (50% sodium chloride)-assisted laser-assisted subepithelial keratectomy (HS-LASEK) vs 20% alcohol-assisted LASER (A-LASEK). Setting: American Laser Medical Center, Rishon Le-Zion, Israel. Methods: Fifty-two consecutive eyes (26 patients) were randomized to HS-LASEK (30 eyes) and A-LASEK (22 eyes) groups. The patients' eyes were examined, refracted, and photographed at 1 day, 5 days, 2 weeks, and 1 month postoperatively by a masked physician. Corneal topography and confocal examination were performed before and 1 month after surgery. Main Outcome Measures: The predictability, accuracy, and visual recovery of HS-LASEK vs A-LASEK in the first postoperative month. Results: The accuracy of HS-LASEK was similar and sometimes better than A-LASEK. Two weeks after surgery, 17 eyes (57%) in the HS-LASEK group and 10 eyes (46%) in the A-LASEK group were within ± 0.5 diopter of the intended refractive correction (P<.05). At all time points eyes in the HS-LASEK group had better best-corrected visual acuity than eyes in the A-LASEK group, although the uncorrected visual acuity was similar. Eighteen (61%) of the HS-LASEK-treated eyes and 12 (55%) of the A-LASEK-treated eyes had an epithelial defect after surgery. The HS-LASEK-treated eyes had significantly larger epithelial defects. The resolution of the defects was faster in the HS-LASEK-treated eyes (mean ± SD, 4.5 ± 0.4 days vs 5.8 ± 0.2 days, P = .002). The subepithelial scar was thicker in A-LASEK-treated eyes. Conclusions: Hypertonic saline-assisted LASEK provides good postoperative accuracy, safety, and a similar rate of complications. In view of recent evidence regarding the epithelial toxic effects of alcohol, HS-LASEK might be a better treatment alternative.
UR - http://www.scopus.com/inward/record.url?scp=13244251025&partnerID=8YFLogxK
U2 - 10.1001/archopht.123.2.171
DO - 10.1001/archopht.123.2.171
M3 - Article
AN - SCOPUS:13244251025
SN - 0003-9950
VL - 123
SP - 171
EP - 176
JO - Archives of Ophthalmology
JF - Archives of Ophthalmology
IS - 2
ER -