Alginate biomaterial for the treatment of myocardial infarction: Progress, translational strategies, and clinical outlook. From ocean algae to patient bedside.

Emil Ruvinov, Smadar Cohen

Research output: Contribution to journalReview articlepeer-review

166 Scopus citations

Abstract

Alginate biomaterial is widely utilized for tissue engineering and regeneration due to its biocompatibility, non-thrombogenic nature, mild and physical gelation process, and the resemblance of its hydrogel matrix texture and stiffness to that of the extracellular matrix. In this review, we describe the versatile biomedical applications of alginate, from its use as a supporting cardiac implant in patients after acute myocardial infarction (MI) to its employment as a vehicle for stem cell delivery and for the controlled delivery and presentation of multiple combinations of bioactive molecules and regenerative factors into the heart. Preclinical and first-in-man clinical trials are described in details, showing the therapeutic potential of injectable acellular alginate implants to inhibit the damaging processes after MI, leading to myocardial repair and tissue reconstruction.

Original languageEnglish
Pages (from-to)54-76
Number of pages23
JournalAdvanced Drug Delivery Reviews
Volume96
DOIs
StatePublished - 15 Jan 2016

Keywords

  • Affinity binding
  • Alginate
  • Biomaterials
  • Clinical trials
  • Myocardial infarction
  • Regeneration
  • Scaffolds
  • Tissue engineering

ASJC Scopus subject areas

  • Pharmaceutical Science

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