Allosteric effects in coiled-coil proteins folding and lanthanide-ion binding

Manickasundaram Samiappan, Samaa Alasibi, Rivka Cohen-Luria, Abraham Shanzer, Gonen Ashkenasy

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Peptide sequences modified with lanthanide-chelating groups at their N-termini, or at their lysine side chains, were synthesized, and new Ln(III) complexes were characterized. We show that partial folding of the conjugates to form trimer coiled coil structures induces coordination of lanthanides to the ligand, which in turn further stabilizes the 3D structure.

Original languageEnglish
Pages (from-to)9577-9579
Number of pages3
JournalChemical Communications
Issue number77
StatePublished - 29 Aug 2012

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


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