Alopecia Areata as a Proximal Risk Factor for the Development of Comorbid Depression: A Population-based Study

Dana Tzur Bitan, Daniella Berzin, Khalaf Kridin, Yaron Sela, Arnon Cohen

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Alopecia areata and depression tend to co-occur; however, their temporal association has not been comprehensively investigated. The aim of this study was to examine the temporal association between alopecia areata and depression. The study included only cases with a comorbid presentation of alopecia areata and depression (n = 1,936), extracted from the databases of the Clalit Health Services, Israel. Survival analyses were used to assess the cumulative probability of receiving alopecia areata as comorbid diagnosis in the years following depression, and vice versa, compared with the opposite trajectory. The results indicate that patients with alopecia areata had greater odds of subsequent depression within 2 years from alopecia areata diagnosis, and showed a steeper increase in cumulative probability of depression as time progressed (log-rank =336.38, p < 0.001), compared with the opposite trajectory. All patients with alopecia areata had comorbid depression within 10 years of alopecia areata, compared with 70% of depression patients receiving diagnoses of comorbid alopecia areata within the same time-frame.

Original languageEnglish
Article numberadv00669
JournalActa Dermato-Venereologica
Volume102
DOIs
StatePublished - 1 Jan 2022
Externally publishedYes

Keywords

  • alopecia areata
  • comorbidity: temporal precedence
  • depression

ASJC Scopus subject areas

  • Dermatology

Fingerprint

Dive into the research topics of 'Alopecia Areata as a Proximal Risk Factor for the Development of Comorbid Depression: A Population-based Study'. Together they form a unique fingerprint.

Cite this