Alpha cyclotron production studies of the alpha emitter 211At/211gPo for high-let metabolic radiotherapy

S. Morzenti; M. L. Bonardi; F. Groppi; C. Zona; L. Canella; E. Menapace; Z. B. Alfassi; K. Abbas; U. Holzwarth

Alpha cyclotron production studies of the alpha emitter ²¹¹At/^211gPo for high-let metabolic radiotherapy

S. Morzenti, M. L. Bonardi, F. Groppi, C. Zona, L. Canella, E. Menapace, Z. B. Alfassi, K. Abbas, U. Holzwarth

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

A series of high specific activity accelerator-produced radionuclides in no-carrier-added (NCA) form, for uses in metabolic radiotherapy and for PET, has been investigated and produced at JRC-Ispra Cyclotron Laboratory. In this study we present, in particular, the NCA ²¹¹At/^211gPo (LET = 130 eV.nm^-1, t_1/2= 7.214 h), produced by ²⁰⁹Bi(α,2n) reaction, with internal spike of gamma emitter ²¹⁰At (e.g. negligible amount of ²¹⁰Po as radiotoxic long-lived impurity), for high-LET targeted radiotherapy and immunoradiotherapy. A selective radiochemical separation, based on liquid/liquid extraction, of At radionuclides from Bi target and Po impurities has been developed. High resolution gamma, X and alpha spectrometric techniques have been adopted for quality controls of different radiochemical fractions.

Original language	English
Title of host publication	Astroparticle, Particle and Space Physics, Detectors and Medical Physics Applications - Proceedings of the 9th Conference
Pages	742-746
Number of pages	5
State	Published - 1 Dec 2006
Event	International Conference on Advanced Technology and Particle Physics, ICATPP 2005 - Como, Italy Duration: 17 Oct 2005 → 21 Oct 2005

Publication series

Name	Astroparticle, Particle and Space Physics, Detectors and Medical Physics Applications - Proceedings of the 9th Conference

Conference

Conference	International Conference on Advanced Technology and Particle Physics, ICATPP 2005
Country/Territory	Italy
City	Como
Period	17/10/05 → 21/10/05

ASJC Scopus subject areas

Astronomy and Astrophysics
Nuclear and High Energy Physics

Cite this

Morzenti, S., Bonardi, M. L., Groppi, F., Zona, C., Canella, L., Menapace, E., Alfassi, Z. B., Abbas, K., & Holzwarth, U. (2006). Alpha cyclotron production studies of the alpha emitter ²¹¹At/^211gPo for high-let metabolic radiotherapy. In Astroparticle, Particle and Space Physics, Detectors and Medical Physics Applications - Proceedings of the 9th Conference (pp. 742-746). (Astroparticle, Particle and Space Physics, Detectors and Medical Physics Applications - Proceedings of the 9th Conference).

Morzenti, S. ; Bonardi, M. L. ; Groppi, F. et al. / Alpha cyclotron production studies of the alpha emitter ²¹¹At/^211gPo for high-let metabolic radiotherapy. Astroparticle, Particle and Space Physics, Detectors and Medical Physics Applications - Proceedings of the 9th Conference. 2006. pp. 742-746 (Astroparticle, Particle and Space Physics, Detectors and Medical Physics Applications - Proceedings of the 9th Conference).

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title = "Alpha cyclotron production studies of the alpha emitter 211At/211gPo for high-let metabolic radiotherapy",

abstract = "A series of high specific activity accelerator-produced radionuclides in no-carrier-added (NCA) form, for uses in metabolic radiotherapy and for PET, has been investigated and produced at JRC-Ispra Cyclotron Laboratory. In this study we present, in particular, the NCA 211At/211gPo (LET = 130 eV.nm-1, t1/2= 7.214 h), produced by 209Bi(α,2n) reaction, with internal spike of gamma emitter 210At (e.g. negligible amount of 210Po as radiotoxic long-lived impurity), for high-LET targeted radiotherapy and immunoradiotherapy. A selective radiochemical separation, based on liquid/liquid extraction, of At radionuclides from Bi target and Po impurities has been developed. High resolution gamma, X and alpha spectrometric techniques have been adopted for quality controls of different radiochemical fractions.",

author = "S. Morzenti and Bonardi, {M. L.} and F. Groppi and C. Zona and L. Canella and E. Menapace and Alfassi, {Z. B.} and K. Abbas and U. Holzwarth",

year = "2006",

month = dec,

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language = "English",

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series = "Astroparticle, Particle and Space Physics, Detectors and Medical Physics Applications - Proceedings of the 9th Conference",

pages = "742--746",

booktitle = "Astroparticle, Particle and Space Physics, Detectors and Medical Physics Applications - Proceedings of the 9th Conference",

note = "International Conference on Advanced Technology and Particle Physics, ICATPP 2005 ; Conference date: 17-10-2005 Through 21-10-2005",

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Morzenti, S, Bonardi, ML, Groppi, F, Zona, C, Canella, L, Menapace, E, Alfassi, ZB, Abbas, K & Holzwarth, U 2006, Alpha cyclotron production studies of the alpha emitter ²¹¹At/^211gPo for high-let metabolic radiotherapy. in Astroparticle, Particle and Space Physics, Detectors and Medical Physics Applications - Proceedings of the 9th Conference. Astroparticle, Particle and Space Physics, Detectors and Medical Physics Applications - Proceedings of the 9th Conference, pp. 742-746, International Conference on Advanced Technology and Particle Physics, ICATPP 2005, Como, Italy, 17/10/05.

Alpha cyclotron production studies of the alpha emitter ²¹¹At/^211gPo for high-let metabolic radiotherapy. / Morzenti, S.; Bonardi, M. L.; Groppi, F. et al.
Astroparticle, Particle and Space Physics, Detectors and Medical Physics Applications - Proceedings of the 9th Conference. 2006. p. 742-746 (Astroparticle, Particle and Space Physics, Detectors and Medical Physics Applications - Proceedings of the 9th Conference).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Morzenti, S.

AU - Bonardi, M. L.

AU - Groppi, F.

AU - Zona, C.

AU - Canella, L.

AU - Menapace, E.

AU - Alfassi, Z. B.

AU - Abbas, K.

AU - Holzwarth, U.

PY - 2006/12/1

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N2 - A series of high specific activity accelerator-produced radionuclides in no-carrier-added (NCA) form, for uses in metabolic radiotherapy and for PET, has been investigated and produced at JRC-Ispra Cyclotron Laboratory. In this study we present, in particular, the NCA 211At/211gPo (LET = 130 eV.nm-1, t1/2= 7.214 h), produced by 209Bi(α,2n) reaction, with internal spike of gamma emitter 210At (e.g. negligible amount of 210Po as radiotoxic long-lived impurity), for high-LET targeted radiotherapy and immunoradiotherapy. A selective radiochemical separation, based on liquid/liquid extraction, of At radionuclides from Bi target and Po impurities has been developed. High resolution gamma, X and alpha spectrometric techniques have been adopted for quality controls of different radiochemical fractions.

AB - A series of high specific activity accelerator-produced radionuclides in no-carrier-added (NCA) form, for uses in metabolic radiotherapy and for PET, has been investigated and produced at JRC-Ispra Cyclotron Laboratory. In this study we present, in particular, the NCA 211At/211gPo (LET = 130 eV.nm-1, t1/2= 7.214 h), produced by 209Bi(α,2n) reaction, with internal spike of gamma emitter 210At (e.g. negligible amount of 210Po as radiotoxic long-lived impurity), for high-LET targeted radiotherapy and immunoradiotherapy. A selective radiochemical separation, based on liquid/liquid extraction, of At radionuclides from Bi target and Po impurities has been developed. High resolution gamma, X and alpha spectrometric techniques have been adopted for quality controls of different radiochemical fractions.

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M3 - Conference contribution

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SN - 9789812567987

T3 - Astroparticle, Particle and Space Physics, Detectors and Medical Physics Applications - Proceedings of the 9th Conference

SP - 742

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BT - Astroparticle, Particle and Space Physics, Detectors and Medical Physics Applications - Proceedings of the 9th Conference

T2 - International Conference on Advanced Technology and Particle Physics, ICATPP 2005

Y2 - 17 October 2005 through 21 October 2005

ER -

Morzenti S, Bonardi ML, Groppi F, Zona C, Canella L, Menapace E et al. Alpha cyclotron production studies of the alpha emitter ²¹¹At/^211gPo for high-let metabolic radiotherapy. In Astroparticle, Particle and Space Physics, Detectors and Medical Physics Applications - Proceedings of the 9th Conference. 2006. p. 742-746. (Astroparticle, Particle and Space Physics, Detectors and Medical Physics Applications - Proceedings of the 9th Conference).