ALSUntangled #67: rituximab

Xiaoyan Li, Carmel Armon, Paul Barkhaus, Benjamin Barnes, Michael Benatar, Tulio Bertorini, Mark Bromberg, Gregory T. Carter, Jesse Crayle, Merit Cudkowicz, Mazen Dimachkie, Eva L. Feldman, Jonathan Glass, Jill Goslinga, Terry Heiman-Patterson, Sartaj Jhooty, Rachel Lichtenstein, Isaac Lund, Christopher Mcdermott, Gary PatteeKaitlyn Pierce, Dylan Ratner, Kristiana Salmon, Paul Wicks, Richard Bedlack

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


ALSUntangled reviews alternative and off-label treatments on behalf of people with ALS who ask about them. Here we review rituximab, a drug which specifically depletes B lymphocytes. We show a current lack of evidence for a role of these cells in ALS progression. The one patient we found who described using Rituximab for their ALS found no benefit. Given all this, and the known serious risks of rituximab, we advise against its use as an ALS treatment.

Original languageEnglish
Pages (from-to)544-547
Number of pages4
JournalAmyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Issue number5-6
StatePublished - 1 Jan 2023


  • ALS
  • neuroinflammation
  • off-label treatment
  • rituximab

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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