Altered interhemispheric signal propagation in schizophrenia and depression

Jeanette Hui, Reza Zomorrodi, Pantelis Lioumis, Elnaz Ensafi, Daphne Voineskos, Aristotle Voineskos, Itay Hadas, Tarek K. Rajji, Daniel M. Blumberger, Zafiris J. Daskalakis

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Objective: Altered interhemispheric connectivity is implicated in the pathophysiology of schizophrenia (SCZ) and major depressive disorder (MDD) and may account for deficits in lateralized cognitive processes. We measured transcranial magnetic stimulation evoked interhemispheric signal propagation (ISP), a non-invasive measure of transcallosal connectivity, and hypothesized that the SCZ and MDD groups will have increased ISP compared to healthy controls. Methods: We evaluated ISP over the dorsolateral prefrontal cortex in 34 patients with SCZ and 34 patients with MDD compared to 32 age and sex-matched healthy controls. Results: ISP was significantly increased in patients with SCZ and patients with MDD compared to healthy controls but did not differ between patient groups. There were no effects of antidepressant, antipsychotic, and benzodiazepine medications on ISP and our results remained unchanged after re-analysis with a region of interest method. Conclusion: Altered ISP was found in both SCZ and MDD patient groups. This indicates that disruptions of interhemispheric signaling processes can be indexed with ISP across psychiatric populations. Significance: These findings enhance our knowledge of the physiological mechanisms of interhemispheric imbalances in SCZ and MDD, which may serve as potential treatment targets in future patients.

Original languageEnglish
Pages (from-to)1604-1611
Number of pages8
JournalClinical Neurophysiology
Issue number7
StatePublished - 1 Jul 2021
Externally publishedYes


  • Depression
  • Electroencephalography
  • Prefrontal cortex
  • Schizophrenia
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)


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