TY - JOUR
T1 - ALUMINIUM TOXICITY IN RATS
AU - Berlyne, G. M.
AU - Ben Ari, J.
AU - Knopf, E.
AU - Yagil, R.
AU - Weinberger, G.
AU - Danovitch, G. M.
N1 - Funding Information:
and administrative assistance, and Dr. J. Geerling for advice and criticism. Investigations were supported by grant G.O. 683-61 from the Dutch Organisation for Health Research T.N.O., and by grant from the Kidney Foundation in the Netherlands.
PY - 1972/3/11
Y1 - 1972/3/11
N2 - Aluminium intoxication has been demonstrated in the uræmic and non-uræmic rat after modest doses of oral and parenteral aluminium salts. The clinical syndrome is associated with periorbital bleeding, lethargy, anorexia, and death. Plasma-levels of aluminium were greatly raised, as were tissue levels in liver, heart, striated muscle, brain, and bone. Histological changes were found in the cornea. Liver oxygen consumption was reduced by giving the animals aluminium salts before death or by adding aluminium in vitro to normal liver homogenates. It is recommended that aluminium salts should be withdrawn from use in patients with renal failure and their use restricted in normal persons pending clarification of the issue.
AB - Aluminium intoxication has been demonstrated in the uræmic and non-uræmic rat after modest doses of oral and parenteral aluminium salts. The clinical syndrome is associated with periorbital bleeding, lethargy, anorexia, and death. Plasma-levels of aluminium were greatly raised, as were tissue levels in liver, heart, striated muscle, brain, and bone. Histological changes were found in the cornea. Liver oxygen consumption was reduced by giving the animals aluminium salts before death or by adding aluminium in vitro to normal liver homogenates. It is recommended that aluminium salts should be withdrawn from use in patients with renal failure and their use restricted in normal persons pending clarification of the issue.
UR - http://www.scopus.com/inward/record.url?scp=0015502392&partnerID=8YFLogxK
U2 - 10.1016/S0140-6736(72)90357-1
DO - 10.1016/S0140-6736(72)90357-1
M3 - Article
C2 - 4110051
AN - SCOPUS:0015502392
SN - 0140-6736
VL - 299
SP - 564
EP - 568
JO - The Lancet
JF - The Lancet
IS - 7750
ER -