G. M. Berlyne, J. Ben Ari, E. Knopf, R. Yagil, G. Weinberger, G. M. Danovitch

Research output: Contribution to journalArticlepeer-review

120 Scopus citations


Aluminium intoxication has been demonstrated in the uræmic and non-uræmic rat after modest doses of oral and parenteral aluminium salts. The clinical syndrome is associated with periorbital bleeding, lethargy, anorexia, and death. Plasma-levels of aluminium were greatly raised, as were tissue levels in liver, heart, striated muscle, brain, and bone. Histological changes were found in the cornea. Liver oxygen consumption was reduced by giving the animals aluminium salts before death or by adding aluminium in vitro to normal liver homogenates. It is recommended that aluminium salts should be withdrawn from use in patients with renal failure and their use restricted in normal persons pending clarification of the issue.

Original languageEnglish
Pages (from-to)564-568
Number of pages5
JournalThe Lancet
Issue number7750
StatePublished - 11 Mar 1972

ASJC Scopus subject areas

  • Medicine (all)


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