ALUMINIUM TOXICITY IN RATS

G. M. Berlyne; J. Ben Ari; E. Knopf; R. Yagil; G. Weinberger; G. M. Danovitch

doi:10.1016/S0140-6736(72)90357-1

ALUMINIUM TOXICITY IN RATS

G. M. Berlyne
, J. Ben Ari
, E. Knopf
, R. Yagil
, G. Weinberger
, G. M. Danovitch

Physiology and Cell Biology

Research output: Contribution to journal › Article › peer-review

122 Scopus citations

Abstract

Aluminium intoxication has been demonstrated in the uræmic and non-uræmic rat after modest doses of oral and parenteral aluminium salts. The clinical syndrome is associated with periorbital bleeding, lethargy, anorexia, and death. Plasma-levels of aluminium were greatly raised, as were tissue levels in liver, heart, striated muscle, brain, and bone. Histological changes were found in the cornea. Liver oxygen consumption was reduced by giving the animals aluminium salts before death or by adding aluminium in vitro to normal liver homogenates. It is recommended that aluminium salts should be withdrawn from use in patients with renal failure and their use restricted in normal persons pending clarification of the issue.

Original language	English
Pages (from-to)	564-568
Number of pages	5
Journal	The Lancet
Volume	299
Issue number	7750
DOIs	https://doi.org/10.1016/S0140-6736(72)90357-1
State	Published - 11 Mar 1972

ASJC Scopus subject areas

General Medicine

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10.1016/S0140-6736(72)90357-1

Cite this

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title = "ALUMINIUM TOXICITY IN RATS",

abstract = "Aluminium intoxication has been demonstrated in the ur{\ae}mic and non-ur{\ae}mic rat after modest doses of oral and parenteral aluminium salts. The clinical syndrome is associated with periorbital bleeding, lethargy, anorexia, and death. Plasma-levels of aluminium were greatly raised, as were tissue levels in liver, heart, striated muscle, brain, and bone. Histological changes were found in the cornea. Liver oxygen consumption was reduced by giving the animals aluminium salts before death or by adding aluminium in vitro to normal liver homogenates. It is recommended that aluminium salts should be withdrawn from use in patients with renal failure and their use restricted in normal persons pending clarification of the issue.",

author = "Berlyne, \{G. M.\} and \{Ben Ari\}, J. and E. Knopf and R. Yagil and G. Weinberger and Danovitch, \{G. M.\}",

note = "Funding Information: and administrative assistance, and Dr. J. Geerling for advice and criticism. Investigations were supported by grant G.O. 683-61 from the Dutch Organisation for Health Research T.N.O., and by grant from the Kidney Foundation in the Netherlands.",

year = "1972",

month = mar,

day = "11",

doi = "10.1016/S0140-6736(72)90357-1",

language = "English",

volume = "299",

pages = "564--568",

journal = "The Lancet",

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AU - Berlyne, G. M.

AU - Ben Ari, J.

AU - Knopf, E.

AU - Yagil, R.

AU - Weinberger, G.

AU - Danovitch, G. M.

N1 - Funding Information: and administrative assistance, and Dr. J. Geerling for advice and criticism. Investigations were supported by grant G.O. 683-61 from the Dutch Organisation for Health Research T.N.O., and by grant from the Kidney Foundation in the Netherlands.

PY - 1972/3/11

Y1 - 1972/3/11

N2 - Aluminium intoxication has been demonstrated in the uræmic and non-uræmic rat after modest doses of oral and parenteral aluminium salts. The clinical syndrome is associated with periorbital bleeding, lethargy, anorexia, and death. Plasma-levels of aluminium were greatly raised, as were tissue levels in liver, heart, striated muscle, brain, and bone. Histological changes were found in the cornea. Liver oxygen consumption was reduced by giving the animals aluminium salts before death or by adding aluminium in vitro to normal liver homogenates. It is recommended that aluminium salts should be withdrawn from use in patients with renal failure and their use restricted in normal persons pending clarification of the issue.

AB - Aluminium intoxication has been demonstrated in the uræmic and non-uræmic rat after modest doses of oral and parenteral aluminium salts. The clinical syndrome is associated with periorbital bleeding, lethargy, anorexia, and death. Plasma-levels of aluminium were greatly raised, as were tissue levels in liver, heart, striated muscle, brain, and bone. Histological changes were found in the cornea. Liver oxygen consumption was reduced by giving the animals aluminium salts before death or by adding aluminium in vitro to normal liver homogenates. It is recommended that aluminium salts should be withdrawn from use in patients with renal failure and their use restricted in normal persons pending clarification of the issue.

UR - https://www.scopus.com/pages/publications/0015502392

U2 - 10.1016/S0140-6736(72)90357-1

DO - 10.1016/S0140-6736(72)90357-1

M3 - Article

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AN - SCOPUS:0015502392

SN - 0140-6736

VL - 299

SP - 564

EP - 568

JO - The Lancet

JF - The Lancet

IS - 7750

ER -

ALUMINIUM TOXICITY IN RATS

Abstract

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