Amberlyst-15 mediated synthesis of 2-substituted 2,3-dihydroquinazolin- 4(1H)-ones and their crystal structure analysis

P. Vns Murthy; D. Rambabu; G. Rama Krishna; C. Malla Reddy; K. R.S. Prasad; M. V. Basaveswara Rao; Manojit Pal

doi:10.1016/j.tetlet.2011.12.023

Amberlyst-15 mediated synthesis of 2-substituted 2,3-dihydroquinazolin- 4(1H)-ones and their crystal structure analysis

P. Vns Murthy, D. Rambabu, G. Rama Krishna, C. Malla Reddy, K. R.S. Prasad, M. V. Basaveswara Rao, Manojit Pal

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61 Scopus citations

Abstract

An efficient and clean method has been developed for the synthesis of 2-substituted 2,3-dihydroquinazolin-4(1H)-ones using Amberlyst-15 as a recyclable catalyst. A variety of dihydroquinazolinones were prepared from 2-aminobenzamide and aldehydes under mild conditions in excellent yields. Further structure elaboration of one compound and the crystal structure analysis and hydrogen bonding patterns of the two compounds prepared by using this methodology is presented.

Original language	English
Pages (from-to)	863-867
Number of pages	5
Journal	Tetrahedron Letters
Volume	53
Issue number	7
DOIs	https://doi.org/10.1016/j.tetlet.2011.12.023
State	Published - 15 Feb 2012
Externally published	Yes

Keywords

2,3-Dihydroquinazolin-4(1H)-ones
Aldehydes
Amberlyst-15

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2011.12.023

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title = "Amberlyst-15 mediated synthesis of 2-substituted 2,3-dihydroquinazolin- 4(1H)-ones and their crystal structure analysis",

abstract = "An efficient and clean method has been developed for the synthesis of 2-substituted 2,3-dihydroquinazolin-4(1H)-ones using Amberlyst-15 as a recyclable catalyst. A variety of dihydroquinazolinones were prepared from 2-aminobenzamide and aldehydes under mild conditions in excellent yields. Further structure elaboration of one compound and the crystal structure analysis and hydrogen bonding patterns of the two compounds prepared by using this methodology is presented.",

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T1 - Amberlyst-15 mediated synthesis of 2-substituted 2,3-dihydroquinazolin- 4(1H)-ones and their crystal structure analysis

AU - Vns Murthy, P.

AU - Rambabu, D.

AU - Rama Krishna, G.

AU - Malla Reddy, C.

AU - Prasad, K. R.S.

AU - Basaveswara Rao, M. V.

AU - Pal, Manojit

PY - 2012/2/15

Y1 - 2012/2/15

N2 - An efficient and clean method has been developed for the synthesis of 2-substituted 2,3-dihydroquinazolin-4(1H)-ones using Amberlyst-15 as a recyclable catalyst. A variety of dihydroquinazolinones were prepared from 2-aminobenzamide and aldehydes under mild conditions in excellent yields. Further structure elaboration of one compound and the crystal structure analysis and hydrogen bonding patterns of the two compounds prepared by using this methodology is presented.

AB - An efficient and clean method has been developed for the synthesis of 2-substituted 2,3-dihydroquinazolin-4(1H)-ones using Amberlyst-15 as a recyclable catalyst. A variety of dihydroquinazolinones were prepared from 2-aminobenzamide and aldehydes under mild conditions in excellent yields. Further structure elaboration of one compound and the crystal structure analysis and hydrogen bonding patterns of the two compounds prepared by using this methodology is presented.

KW - 2,3-Dihydroquinazolin-4(1H)-ones

KW - Aldehydes

KW - Amberlyst-15

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M3 - Article

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SN - 0040-4039

VL - 53

SP - 863

EP - 867

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 7

ER -

Amberlyst-15 mediated synthesis of 2-substituted 2,3-dihydroquinazolin- 4(1H)-ones and their crystal structure analysis

Abstract

Keywords

ASJC Scopus subject areas

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