TY - JOUR
T1 - Ambient air pollution, adipokines, and glucose homeostasis
T2 - The Framingham Heart Study
AU - Li, Wenyuan
AU - Dorans, Kirsten S.
AU - Wilker, Elissa H.
AU - Rice, Mary B.
AU - Kloog, Itai
AU - Schwartz, Joel D.
AU - Koutrakis, Petros
AU - Coull, Brent A.
AU - Gold, Diane R.
AU - Meigs, James B.
AU - Fox, Caroline S.
AU - Mittleman, Murray A.
N1 - Funding Information:
This publication was made possible by US Environmental Protection Agency grant numbers RD-834798 and RD-835872 . Its contents are solely the responsibility of the grantee and do not necessarily represent the official views of the US Environmental Protection Agency. Further, US Environmental Protection Agency does not endorse the purchase of any commercial products or services mentioned in the publication. This work was supported by the National Heart, Lung and Blood Institute of the National Institutes of Health (grants HHSN268201500001I , N01-HC 25195 , and T32HL007575 ), the National Institutes of Environmental Health Sciences (grant P01ES09825 , K23ES026204 , R00ES022243 , and P30ES000002 ), the National Institute for Diabetes and Digestive and Kidney Diseases (NIDDK) K24 DK080140 , and the National Institute of General Medical Sciences (grant 1P20GM109036-01A1 ). The contents are solely the responsibility of the grantee and do not necessarily represent the official views of the National Heart, Lung, and Blood Institute; the National Institutes of Health; or the U.S. Department of Health and Human Services.
Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Objective To examine associations of proximity to major roadways, sustained exposure to fine particulate matter (PM2.5), and acute exposure to ambient air pollutants with adipokines and measures of glucose homeostasis among participants living in the northeastern United States. Methods We included 5958 participants from the Framingham Offspring cohort examination cycle 7 (1998–2001) and 8 (2005–2008) and Third Generation cohort examination cycle 1 (2002–2005) and 2 (2008–2011), who did not have type 2 diabetes at the time of examination visit. We calculated 2003 annual average PM2.5 at participants' home address, residential distance to the nearest major roadway, and daily PM2.5, black carbon (BC), sulfate, nitrogen oxides (NOx), and ozone concentrations. We used linear mixed effects models for fasting glucose, insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) which were measured up to twice, and used linear regression models for adiponectin, resistin, leptin, and hemoglobin A1c (HbA1c) which were measured only once, adjusting for demographics, socioeconomic position, lifestyle, time, and seasonality. Results The mean age was 51 years and 55% were women. Participants who lived 64 m (25th percentile) from a major roadway had 0.28% (95% CI: 0.05%, 0.51%) higher fasting plasma glucose than participants who lived 413 m (75th percentile) away, and the association appeared to be driven by participants who lived within 50 m from a major roadway. Higher exposures to 3- to 7-day moving averages of BC and NOx were associated with higher glucose whereas the associations for ozone were negative. The associations otherwise were generally null and did not differ by median age, sex, educational attainment, obesity status, or prediabetes status. Conclusions Living closer to a major roadway or acute exposure to traffic-related air pollutants were associated with dysregulated glucose homeostasis but not with adipokines among participants from the Framingham Offspring and Third Generation cohorts.
AB - Objective To examine associations of proximity to major roadways, sustained exposure to fine particulate matter (PM2.5), and acute exposure to ambient air pollutants with adipokines and measures of glucose homeostasis among participants living in the northeastern United States. Methods We included 5958 participants from the Framingham Offspring cohort examination cycle 7 (1998–2001) and 8 (2005–2008) and Third Generation cohort examination cycle 1 (2002–2005) and 2 (2008–2011), who did not have type 2 diabetes at the time of examination visit. We calculated 2003 annual average PM2.5 at participants' home address, residential distance to the nearest major roadway, and daily PM2.5, black carbon (BC), sulfate, nitrogen oxides (NOx), and ozone concentrations. We used linear mixed effects models for fasting glucose, insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) which were measured up to twice, and used linear regression models for adiponectin, resistin, leptin, and hemoglobin A1c (HbA1c) which were measured only once, adjusting for demographics, socioeconomic position, lifestyle, time, and seasonality. Results The mean age was 51 years and 55% were women. Participants who lived 64 m (25th percentile) from a major roadway had 0.28% (95% CI: 0.05%, 0.51%) higher fasting plasma glucose than participants who lived 413 m (75th percentile) away, and the association appeared to be driven by participants who lived within 50 m from a major roadway. Higher exposures to 3- to 7-day moving averages of BC and NOx were associated with higher glucose whereas the associations for ozone were negative. The associations otherwise were generally null and did not differ by median age, sex, educational attainment, obesity status, or prediabetes status. Conclusions Living closer to a major roadway or acute exposure to traffic-related air pollutants were associated with dysregulated glucose homeostasis but not with adipokines among participants from the Framingham Offspring and Third Generation cohorts.
KW - Adipokines
KW - Air pollution
KW - Epidemiology
KW - Glucose homeostasis
KW - Particulate matter
UR - http://www.scopus.com/inward/record.url?scp=85034416786&partnerID=8YFLogxK
U2 - 10.1016/j.envint.2017.11.010
DO - 10.1016/j.envint.2017.11.010
M3 - Article
AN - SCOPUS:85034416786
SN - 0160-4120
VL - 111
SP - 14
EP - 22
JO - Environment international
JF - Environment international
ER -
