Amino acids as chiral anionic ligands for ruthenium based asymmetric olefin metathesis

Elisa Ivry; Amos Ben-Asuly; Israel Goldberg; N. Gabriel Lemcoff

doi:10.1039/c5cc00052a

Amino acids as chiral anionic ligands for ruthenium based asymmetric olefin metathesis

Elisa Ivry, Amos Ben-Asuly, Israel Goldberg, N. Gabriel Lemcoff

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Several amino acid ligands were introduced into the Hoveyda-Grubbs 2nd generation complex by a facile anionic ligand exchange. The chiral pre-catalysts obtained displayed enantioselectivity in asymmetric ring-closing and ring-opening cross-metathesis reactions. Reduction of the lability of the carboxylate ligands was found to be cardinal for improving the observed enantiomeric product enrichment.

Original language	English
Pages (from-to)	3870-3873
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	18
DOIs	https://doi.org/10.1039/c5cc00052a
State	Published - 4 Mar 2015

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c5cc00052a

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title = "Amino acids as chiral anionic ligands for ruthenium based asymmetric olefin metathesis",

abstract = "Several amino acid ligands were introduced into the Hoveyda-Grubbs 2nd generation complex by a facile anionic ligand exchange. The chiral pre-catalysts obtained displayed enantioselectivity in asymmetric ring-closing and ring-opening cross-metathesis reactions. Reduction of the lability of the carboxylate ligands was found to be cardinal for improving the observed enantiomeric product enrichment.",

author = "Elisa Ivry and Amos Ben-Asuly and Israel Goldberg and Lemcoff, {N. Gabriel}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2015.",

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T1 - Amino acids as chiral anionic ligands for ruthenium based asymmetric olefin metathesis

AU - Ivry, Elisa

AU - Ben-Asuly, Amos

AU - Goldberg, Israel

AU - Lemcoff, N. Gabriel

PY - 2015/3/4

Y1 - 2015/3/4

N2 - Several amino acid ligands were introduced into the Hoveyda-Grubbs 2nd generation complex by a facile anionic ligand exchange. The chiral pre-catalysts obtained displayed enantioselectivity in asymmetric ring-closing and ring-opening cross-metathesis reactions. Reduction of the lability of the carboxylate ligands was found to be cardinal for improving the observed enantiomeric product enrichment.

AB - Several amino acid ligands were introduced into the Hoveyda-Grubbs 2nd generation complex by a facile anionic ligand exchange. The chiral pre-catalysts obtained displayed enantioselectivity in asymmetric ring-closing and ring-opening cross-metathesis reactions. Reduction of the lability of the carboxylate ligands was found to be cardinal for improving the observed enantiomeric product enrichment.

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U2 - 10.1039/c5cc00052a

DO - 10.1039/c5cc00052a

M3 - Article

AN - SCOPUS:84923164306

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VL - 51

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EP - 3873

JO - Chemical Communications

JF - Chemical Communications

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ER -

Amino acids as chiral anionic ligands for ruthenium based asymmetric olefin metathesis

Abstract

ASJC Scopus subject areas

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