Amino acids as chiral anionic ligands for ruthenium based asymmetric olefin metathesis

Elisa Ivry, Amos Ben-Asuly, Israel Goldberg, N. Gabriel Lemcoff

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Several amino acid ligands were introduced into the Hoveyda-Grubbs 2nd generation complex by a facile anionic ligand exchange. The chiral pre-catalysts obtained displayed enantioselectivity in asymmetric ring-closing and ring-opening cross-metathesis reactions. Reduction of the lability of the carboxylate ligands was found to be cardinal for improving the observed enantiomeric product enrichment.

Original languageEnglish
Pages (from-to)3870-3873
Number of pages4
JournalChemical Communications
Volume51
Issue number18
DOIs
StatePublished - 4 Mar 2015

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