Aminoisobutyric acid leads a fluorescent syn-bimane LASER probe across the blood-brain barrier

Inbal Lapidot, Danny Baranes, Albert Pinhasov, Gary Gellerman, Amnon Albeck, Flavio Grynszpan, Shimon E. Shatzmiller

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Penetration of the blood brain barrier (BBB) by appropriate fluorescent probes remains a challenge in optical imaging and diagnostics. We designed, synthesized and observed the in vivo BBB penetration of a LASER syn-bimane probe. Results demonstrate that the Aib transporter unit in our probe may lead a fluorescent bimanyl moiety across the BBB.

Original languageEnglish
Pages (from-to)48-53
Number of pages6
JournalMedicinal Chemistry
Volume12
Issue number1
DOIs
StatePublished - 1 Feb 2016
Externally publishedYes

Keywords

  • Blood-brain barrier
  • Fluorescence microscopy
  • Fluorescent probe
  • Laser dye
  • Syn-bimane

ASJC Scopus subject areas

  • Drug Discovery

Fingerprint

Dive into the research topics of 'Aminoisobutyric acid leads a fluorescent syn-bimane LASER probe across the blood-brain barrier'. Together they form a unique fingerprint.

Cite this