Amniotic fluid concentration of 5-hydroxyeicosatetraenoic acid is increased in human parturition at term

R. Romero, Ying King Wu, M. Mazor, J. C. Hobbins, M. D. Mitchell

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

5-hydroxyeicosatetraenoic acid (5-HETE) is an arachidonate lipoxygenase product capable of stimulating uterine contractility in a dose-dependent manner in vitro. The purpose of this study was to determine if spontaneous human labor at term is associated with changes in the concentration of this metabolite in amniotic fluid. Fluid was retrieved from 36 women not in labor and from 30 women in active labor at term. 5-HETE was determined by radioimmunoassay. The median amniotic fluid concentration of 5-HETE of women in labor was significantly greater than that of women not in labor (3538 pg/ml vs. 1977 pg/ml, respectively; p = 0.05). This observation is consistent with activation of the lipoxygenase pathway of arachidonic acid metabolism during spontaneous human parturition at term.

Original languageEnglish
Pages (from-to)81-83
Number of pages3
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume35
Issue number2
DOIs
StatePublished - 1 Jan 1989
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology

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