Amniotic fluid concentration of 5-hydroxyeicosatetraenoic acid is increased in human parturition at term

R. Romero; Ying King Wu; M. Mazor; J. C. Hobbins; M. D. Mitchell

doi:10.1016/0952-3278(89)90169-5

Amniotic fluid concentration of 5-hydroxyeicosatetraenoic acid is increased in human parturition at term

R. Romero, Ying King Wu, M. Mazor, J. C. Hobbins, M. D. Mitchell

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

5-hydroxyeicosatetraenoic acid (5-HETE) is an arachidonate lipoxygenase product capable of stimulating uterine contractility in a dose-dependent manner in vitro. The purpose of this study was to determine if spontaneous human labor at term is associated with changes in the concentration of this metabolite in amniotic fluid. Fluid was retrieved from 36 women not in labor and from 30 women in active labor at term. 5-HETE was determined by radioimmunoassay. The median amniotic fluid concentration of 5-HETE of women in labor was significantly greater than that of women not in labor (3538 pg/ml vs. 1977 pg/ml, respectively; p = 0.05). This observation is consistent with activation of the lipoxygenase pathway of arachidonic acid metabolism during spontaneous human parturition at term.

Original language	English
Pages (from-to)	81-83
Number of pages	3
Journal	Prostaglandins Leukotrienes and Essential Fatty Acids
Volume	35
Issue number	2
DOIs	https://doi.org/10.1016/0952-3278(89)90169-5
State	Published - 1 Jan 1989
Externally published	Yes

ASJC Scopus subject areas

Clinical Biochemistry
Cell Biology

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10.1016/0952-3278(89)90169-5

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title = "Amniotic fluid concentration of 5-hydroxyeicosatetraenoic acid is increased in human parturition at term",

abstract = "5-hydroxyeicosatetraenoic acid (5-HETE) is an arachidonate lipoxygenase product capable of stimulating uterine contractility in a dose-dependent manner in vitro. The purpose of this study was to determine if spontaneous human labor at term is associated with changes in the concentration of this metabolite in amniotic fluid. Fluid was retrieved from 36 women not in labor and from 30 women in active labor at term. 5-HETE was determined by radioimmunoassay. The median amniotic fluid concentration of 5-HETE of women in labor was significantly greater than that of women not in labor (3538 pg/ml vs. 1977 pg/ml, respectively; p = 0.05). This observation is consistent with activation of the lipoxygenase pathway of arachidonic acid metabolism during spontaneous human parturition at term.",

author = "R. Romero and Wu, {Ying King} and M. Mazor and Hobbins, {J. C.} and Mitchell, {M. D.}",

note = "Funding Information: Supported by grants from the Walter Scott Foundation for Medical Research and NIH grant HD 20747. Dr. Romero is the recipient of a Physician Scientist Award from the National Institutes of Health. Correspondence: Roberto Romero, M.D. Yale University School of Medic&, Department of Obstetrics and Gynecology, PO Box 3333, New Haven, CT 06510",

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AU - Romero, R.

AU - Wu, Ying King

AU - Mazor, M.

AU - Hobbins, J. C.

AU - Mitchell, M. D.

N1 - Funding Information: Supported by grants from the Walter Scott Foundation for Medical Research and NIH grant HD 20747. Dr. Romero is the recipient of a Physician Scientist Award from the National Institutes of Health. Correspondence: Roberto Romero, M.D. Yale University School of Medic&, Department of Obstetrics and Gynecology, PO Box 3333, New Haven, CT 06510

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N2 - 5-hydroxyeicosatetraenoic acid (5-HETE) is an arachidonate lipoxygenase product capable of stimulating uterine contractility in a dose-dependent manner in vitro. The purpose of this study was to determine if spontaneous human labor at term is associated with changes in the concentration of this metabolite in amniotic fluid. Fluid was retrieved from 36 women not in labor and from 30 women in active labor at term. 5-HETE was determined by radioimmunoassay. The median amniotic fluid concentration of 5-HETE of women in labor was significantly greater than that of women not in labor (3538 pg/ml vs. 1977 pg/ml, respectively; p = 0.05). This observation is consistent with activation of the lipoxygenase pathway of arachidonic acid metabolism during spontaneous human parturition at term.

AB - 5-hydroxyeicosatetraenoic acid (5-HETE) is an arachidonate lipoxygenase product capable of stimulating uterine contractility in a dose-dependent manner in vitro. The purpose of this study was to determine if spontaneous human labor at term is associated with changes in the concentration of this metabolite in amniotic fluid. Fluid was retrieved from 36 women not in labor and from 30 women in active labor at term. 5-HETE was determined by radioimmunoassay. The median amniotic fluid concentration of 5-HETE of women in labor was significantly greater than that of women not in labor (3538 pg/ml vs. 1977 pg/ml, respectively; p = 0.05). This observation is consistent with activation of the lipoxygenase pathway of arachidonic acid metabolism during spontaneous human parturition at term.

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Amniotic fluid concentration of 5-hydroxyeicosatetraenoic acid is increased in human parturition at term

Abstract

ASJC Scopus subject areas

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