Amygdala-Hippocampus Coupling is Associated With Aversive Learning

Or Duek, Ifat Levy, Nachshon Korem, Ilan Harpaz-Rotem

Research output: Contribution to journalMeeting Abstractpeer-review


Aversive learning involves both context and emotional coding. While the amygdala has a pivotal role in aversive learning and the hippocampus in context-related learning, the connectivity between the two and its effect on aversive learning was not yet thoroughly studied. In this study we explored the role of amygdala-hippocampus coupling in aversive learning.
In an fMRI experiment, 74 participants underwent an aversive reversal learning paradigm. For each trial, we have calculated the correlation between the amygdala and hippocampal activation, as well as amygdala-vmPFC and amygdala-supramarginal gyrus (a control region). We then tested whether the coupling of amygdala-hippocampus (or other two regions) predicted the skin conductance response above and beyond the amygdala activation.
Comparing amygdala-hippocampal coupling between the different conditions (CS+ with shock, CS+ without shock, and CS-) showed a significant elevation in the shock condition (β=0.06 pConclusions
The process by which aversive learning is acquired and coded in the human brain is still elusive. Our results present evidence for the significant role amygdala-hippocampus coupling plays in encoding this kind of learning.
Original languageEnglish
Pages (from-to)S340-S340
JournalBiological Psychiatry
Issue number9, Supplement
StatePublished - 1 May 2022
Externally publishedYes


  • Fear Memory
  • Fear Learning
  • Hippocampus/Amygdala


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