Amyloid Inhibitors: Lysine-Derived Carbon Dots for Chiral Inhibition of Prion Peptide Fibril Assembly

Elad Arad, Susanta Kumar Bhunia, Jürgen Jopp, Sofiya Kolusheva, Hanna Rapaport, Raz Jelinek

Research output: Contribution to journalArticle

Abstract

In article number 1800006, Raz Jelinek and co-workers report that enantiomeric C-dots, synthesized from either d-Lysine or l-Lysine, interfere with aggregation of the amyloidogenic determinant of the prion protein. The interactions of the chiral Lys-C-dots with the amyloidogenic determinant, as well as with membrane bilayers, appear to be stereoselective, with the l-Lys-C-dots inhibiting amyloidogenic aggregation more effectively than d-Lys-C-dots.
Original languageEnglish
Pages (from-to)1870008
Number of pages1
JournalAdvanced Therapeutics
Volume1
Issue number4
DOIs
StatePublished - 2018

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