An alternate crystal form of gabapentin: A cocrystal with oxalic acid

Mazal Wenger; Joel Bernstein

doi:10.1021/cg7008732

An alternate crystal form of gabapentin: A cocrystal with oxalic acid

Mazal Wenger, Joel Bernstein

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

A cocrystal of gabapentin and oxalic acid has been prepared employing a strategy based on a hydrogen-bonded synthon described by the graph set notation R₄²(8). High throughput techniques and solvent drop grinding were used along with traditional crystallization methods, including crystallization in aqueous solutions at various pH. A number of new solid forms have been detected. The cocrystal of gabapentin and oxalic acid was fully characterized including single crystal structure analysis, which revealed the R₄²(8) synthon.

Original language	English
Pages (from-to)	1595-1598
Number of pages	4
Journal	Crystal Growth and Design
Volume	8
Issue number	5
DOIs	https://doi.org/10.1021/cg7008732
State	Published - 1 May 2008

ASJC Scopus subject areas

General Chemistry
General Materials Science
Condensed Matter Physics

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10.1021/cg7008732

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abstract = "A cocrystal of gabapentin and oxalic acid has been prepared employing a strategy based on a hydrogen-bonded synthon described by the graph set notation R42(8). High throughput techniques and solvent drop grinding were used along with traditional crystallization methods, including crystallization in aqueous solutions at various pH. A number of new solid forms have been detected. The cocrystal of gabapentin and oxalic acid was fully characterized including single crystal structure analysis, which revealed the R42(8) synthon.",

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An alternate crystal form of gabapentin: A cocrystal with oxalic acid

Abstract

ASJC Scopus subject areas

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