An alternative synthetic approach for the construction of tafamidis analogues and its novel derivatives

Dattatray Gaikwad; Rana Chatterjee; Achyuta Nanda Acharya; Rambabu Dandela

doi:10.1016/j.jics.2025.101739

An alternative synthetic approach for the construction of tafamidis analogues and its novel derivatives

Dattatray Gaikwad, Rana Chatterjee, Achyuta Nanda Acharya, Rambabu Dandela

Research output: Contribution to journal › Article › peer-review

Abstract

An alternate synthetic approach has been demonstrated to synthesize novel tafamidis analogues. The present procedure offers an efficient, practical and cost-effective synthetic method to achieve the important scaffold and its extended amide derivatives that may exhibit several biological activities. Furthermore, the strategy has been executed by using affordable reagents, easily available intermediates, and lesser conversion steps, leading to a good yield of the desired compounds.

Original language	English
Article number	101739
Journal	Journal of the Indian Chemical Society
Volume	102
Issue number	7
DOIs	https://doi.org/10.1016/j.jics.2025.101739
State	Published - 1 Jul 2025
Externally published	Yes

Keywords

Amide derivatives
Cost-effective
Tafamidis analogues

ASJC Scopus subject areas

Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
Electrochemistry

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10.1016/j.jics.2025.101739

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abstract = "An alternate synthetic approach has been demonstrated to synthesize novel tafamidis analogues. The present procedure offers an efficient, practical and cost-effective synthetic method to achieve the important scaffold and its extended amide derivatives that may exhibit several biological activities. Furthermore, the strategy has been executed by using affordable reagents, easily available intermediates, and lesser conversion steps, leading to a good yield of the desired compounds.",

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AU - Dandela, Rambabu

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An alternative synthetic approach for the construction of tafamidis analogues and its novel derivatives

Abstract

Keywords

ASJC Scopus subject areas

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