An association between a history of gestational diabetes mellitus and long term risk for ophthalmic complications

Ofer Beharier, Roy Kessous, Ilana Shoham Vardi, Ruslan Sergienko, Ehud Davidson, Eyal Sheiner

Research output: Contribution to journalMeeting Abstractpeer-review

Abstract

Objective
To investigate whether patients with a history of gestational diabetes mellitus (GDM) have an increased risk for subsequent long-term ophthalmic complications.
Study Design
A population-based study compared the incidence of long-term maternal ophthalmic complications in a cohort of women with and without a prior history of GDM. Deliveries occurred between the years 1988-2013, with a mean follow-up duration of 12 years. Excluded from the study were women with known ophthalmic diseases prior to the index pregnancy as well as pre-gestational diabetes. Ophthalmic complications were divided to glaucoma, diabetic retinopathy, macular degeneration and retinal detachment. Kaplan-Meier survival curve was used to estimate cumulative incidence of ophthalmic complications. Cox proportional hazards model was used to estimate the adjusted hazard ratios (HR) for ophthalmic complications.

Results
During the study period, 104,751 deliveries met the inclusion criteria; 9.4% (n=9888) occurred in patients with a diagnosis of GDM during at least one of their pregnancies. Patients with GDM had a significantly higher incidence of ophthalmic complications such as glaucoma, diabetic retinopathy and retinal detachment (table). Using a Kaplan-Meier survival curve, patients with GDM had a significantly higher cumulative incidence of ophthalmic complications (Figure). Using a Cox proportional hazards model, adjusted for maternal age, preeclampsia and obesity, a history of GDM remained independently associated with ophthalmic complications (adjusted HR, 2.0; 95% CI, 1.5-2.7; P=0.001).
Conclusion
Gestational diabetes mellitus is an independent risk factor for long-term maternal ophthalmic complications, including glaucoma, diabetic retinopathy and retinal detachment.
Original languageEnglish GB
Pages (from-to)S338-S338
JournalAmerican Journal of Obstetrics and Gynecology
Volume212
Issue number1
DOIs
StatePublished - Jan 2015

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